Joseph A Lyons
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Explore the profile of Joseph A Lyons including associated specialties, affiliations and a list of published articles.
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23
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2419
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Recent Articles
1.
Brodszkij E, Ryberg C, Lyons J, Juhl D, Nielsen N, Sigalas N, et al.
Small
. 2024 Jun;
20(40):e2401934.
PMID: 38860565
Amphiphilic block copolymer and lipids can be assembled into hybrid vesicles (HVs), which are an alternative to liposomes and polymersomes. Block copolymers that have either poly(sitostryl methacrylate) or statistical copolymers...
2.
Dieudonne T, Kummerer F, Laursen M, Stock C, Flygaard R, Khalid S, et al.
Nat Commun
. 2023 Nov;
14(1):7492.
PMID: 37980352
Asymmetric distribution of phospholipids in eukaryotic membranes is essential for cell integrity, signaling pathways, and vesicular trafficking. P4-ATPases, also known as flippases, participate in creating and maintaining this asymmetry through...
3.
Neumann C, Focht D, Trampari S, Lyons J, Nissen P
Acta Crystallogr F Struct Biol Commun
. 2022 Aug;
78(Pt 8):297-305.
PMID: 35924597
The bacterial amino-acid transporter MhsT from the SLC6A family has been crystallized in complex with different substrates in order to understand the determinants of the substrate specificity of the transporter....
4.
Dieudonne T, Herrera S, Laursen M, Lejeune M, Stock C, Slimani K, et al.
Elife
. 2022 Apr;
11.
PMID: 35416773
P4-ATPases flip lipids from the exoplasmic to the cytosolic leaflet, thus maintaining lipid asymmetry in eukaryotic cell membranes. Mutations in several human P4-ATPase genes are associated with severe diseases, for...
5.
Timcenko M, Dieudonne T, Montigny C, Boesen T, Lyons J, Lenoir G, et al.
J Mol Biol
. 2021 May;
433(16):167062.
PMID: 34023399
P4-ATPases define a eukaryotic subfamily of the P-type ATPases, and are responsible for the transverse flip of specific lipids from the extracellular or luminal leaflet to the cytosolic leaflet of...
6.
Lyons J, Timcenko M, Dieudonne T, Lenoir G, Nissen P
Curr Opin Struct Biol
. 2020 Jun;
63:65-73.
PMID: 32492637
Type 4 P-type ATPases (P4-ATPases) are lipid flippases that drive the active, inward directed translocation (flip) of lipids in eukaryotic membranes. The resulting lipid asymmetry potentiates the membrane and is...
7.
Timcenko M, Lyons J, Januliene D, Ulstrup J, Dieudonne T, Montigny C, et al.
Nature
. 2019 Jun;
571(7765):366-370.
PMID: 31243363
Type 4 P-type ATPases (P4-ATPases) are lipid flippases that drive the active transport of phospholipids from exoplasmic or luminal leaflets to cytosolic leaflets of eukaryotic membranes. The molecular architecture of...
8.
Lyons J, Boggild A, Nissen P, Frauenfeld J
Methods Enzymol
. 2017 Aug;
594:85-99.
PMID: 28779844
Membrane proteins depend on their natural lipid environment for function, which makes them more difficult to study in isolation. A number of approaches that mimic the lipid bilayer of biological...
9.
Azouaoui H, Montigny C, Dieudonne T, Champeil P, Jacquot A, Vazquez-Ibar J, et al.
J Biol Chem
. 2017 Mar;
292(19):7954-7970.
PMID: 28302728
P4-ATPases, also known as phospholipid flippases, are responsible for creating and maintaining transbilayer lipid asymmetry in eukaryotic cell membranes. Here, we use limited proteolysis to investigate the role of the...
10.