Joseph A Loo
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Explore the profile of Joseph A Loo including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Vlahakis N, Flowers C, Liu M, Agdanowski M, Johnson S, Summers J, et al.
bioRxiv
. 2025 Mar;
PMID: 40060639
With the goal of accelerating the discovery of small molecule-protein complexes, we leverage fast, low-dose, event based electron counting microcrystal electron diffraction (MicroED) data collection and native mass spectrometry. This...
2.
Campuzano I, Loo J
J Am Soc Mass Spectrom
. 2025 Mar;
PMID: 40043050
Mass spectrometry (MS) has become an essential tool in virtually all academic, pharmaceutical, and biopharmaceutical analytical laboratories. The specialized and bespoke area of MS research and application of high /...
3.
Silva A, Duarte-Silva S, Martins P, Rodrigues B, Serrenho D, Vilasboas-Campos D, et al.
bioRxiv
. 2025 Feb;
PMID: 39896516
Spinocerebellar ataxia type 3 (SCA3) is a rare inherited neurodegenerative disease caused by the expansion of a polyglutamine repeat in the protease ataxin-3 (Atx3). Despite extensive knowledge of the downstream...
4.
Chiang C, Ohashi M, Le J, Chen P, Zhou Q, Qu S, et al.
Nature
. 2025 Jan;
638(8049):126-132.
PMID: 39880944
Carbon-hydrogen (C-H) bonds are the foundation of essentially every organic molecule, making them an ideal place to do chemical synthesis. The key challenge is achieving selectivity for one particular C(sp)-H...
5.
Goring A, Hale S, Dasika P, Chen Y, Clubb R, Loo J
J Proteome Res
. 2024 Dec;
24(1):77-93.
PMID: 39692319
Toxin-producing strains are the etiological agents of the severe upper respiratory disease, diphtheria. A global phylogenetic analysis revealed that biotype gravis is particularly lethal as it produces diphtheria toxin and...
6.
Wang H, Zhang J, Liao S, Henstra A, Leon D, Erde J, et al.
Sci Adv
. 2024 Dec;
10(50):eadr8596.
PMID: 39671499
Archaea share genomic similarities with Eukarya and cellular architectural similarities with Bacteria, though archaeal and bacterial surface layers (S-layers) differ. Using cellular cryo-electron tomography, we visualized the S-layer lattice surrounding...
7.
Mikawy N, Ramirez C, DeFiglia S, Szot C, Le J, Lantz C, et al.
Mol Cell Proteomics
. 2024 Jul;
23(9):100814.
PMID: 39029587
Protein tandem mass spectrometry (MS/MS) often generates sequence-informative fragments from backbone bond cleavages near the termini. This lack of fragmentation in the protein interior is particularly apparent in native top-down...
8.
Roberts D, Loo J, Tsybin Y, Liu X, Wu S, Chamot-Rooke J, et al.
Nat Rev Methods Primers
. 2024 Jul;
4(1).
PMID: 39006170
Proteoforms, which arise from post-translational modifications, genetic polymorphisms and RNA splice variants, play a pivotal role as drivers in biology. Understanding proteoforms is essential to unravel the intricacies of biological...
9.
Habeck T, Brown K, Des Soye B, Lantz C, Zhou M, Alam N, et al.
Nat Methods
. 2024 May;
21(12):2388-2396.
PMID: 38744918
The combination of native electrospray ionization with top-down fragmentation in mass spectrometry (MS) allows simultaneous determination of the stoichiometry of noncovalent complexes and identification of their component proteoforms and cofactors....
10.
Hou K, Pan H, Shahpasand-Kroner H, Hu C, Abskharon R, Seidler P, et al.
Sci Adv
. 2024 May;
10(18):eadl2991.
PMID: 38691615
Amyloid fibrils of tau are increasingly accepted as a cause of neuronal death and brain atrophy in Alzheimer's disease (AD). Diminishing tau aggregation is a promising strategy in the search...