Jose Perdomo
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Explore the profile of Jose Perdomo including associated specialties, affiliations and a list of published articles.
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27
Citations
678
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Recent Articles
1.
Dupuy A, Liu X, Kong Y, Qi M, Perdomo J, Fenwick J, et al.
Blood Adv
. 2025 Mar;
PMID: 40085945
Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare, but serious, complication of the ChAdOx1 nCOV-19 vaccine. In Australia, the diagnosis of VITT required the detection of antibodies against platelet factor...
2.
Leung H, Ahmadi Z, Lee B, Casey J, Ratnasingam S, McKenzie S, et al.
Blood Adv
. 2024 Sep;
8(22):5744-5752.
PMID: 39293086
Current guidelines for treating vaccine-induced immune thrombotic thrombocytopenia (VITT) recommend nonheparin anticoagulants and IV immunoglobulin (IVIg). However, the efficacy of these treatments remains uncertain due to case studies involving small...
3.
Ellis M, Terreaux A, Alwis I, Smythe R, Perdomo J, Eckly A, et al.
Blood
. 2023 Nov;
143(4):342-356.
PMID: 37922495
Glycoprotein Ibα (GPIbα) is expressed on the surface of platelets and megakaryocytes (MKs) and anchored to the membrane skeleton by filamin A (flnA). Although GPIb and flnA have fundamental roles...
4.
Perdomo J, Leung H
Biology (Basel)
. 2023 Oct;
12(10).
PMID: 37887042
Neutrophil extracellular traps (NETs) are major contributors to inflammation and autoimmunity, playing a key role in the development of thrombotic disorders. NETs, composed of DNA, histones, and numerous other proteins...
5.
Leung H, Perdomo J, Ahmadi Z, Chong B
Bio Protoc
. 2023 Sep;
13(17):e4804.
PMID: 37719068
Platelets play an important role in hemostasis by forming clots and stopping bleeding. In immune thrombotic conditions, platelets and leukocytes are aberrantly activated by pathogenic antibodies resulting in platelet aggregates...
6.
Leung H, Perdomo J, Ahmadi Z, Zheng S, Rashid F, Enjeti A, et al.
Nat Commun
. 2022 Sep;
13(1):5206.
PMID: 36064843
Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare yet serious adverse effect of the adenoviral vector vaccines ChAdOx1 nCoV-19 (AstraZeneca) and Ad26.COV2.S (Janssen) against COVID-19. The mechanisms involved in clot...
7.
Chilingaryan Z, Deshmukh T, Leung H, Perdomo J, Emerson P, Kurup R, et al.
Pathology
. 2021 Sep;
54(1):87-94.
PMID: 34493386
Cardiovascular disease, including myocardial infarction (MI), is the leading cause of death globally. Current antithrombotic medications used during MI treatment are predominantly directed towards platelet inhibition and, to a lesser...
8.
Leung H, Perdomo J, Ahmadi Z, Yan F, McKenzie S, Chong B
Blood Adv
. 2021 Sep;
5(23):5439-5451.
PMID: 34478504
Heparin-induced thrombocytopenia (HIT) is associated with severe and potentially lethal thrombotic complications. NETosis was recently shown to be an important driver of thrombosis in HIT. We investigated the role of...
9.
Rashid F, Clayton Z, Ogawa M, Perdomo J, Hume R, Kizana E, et al.
Int J Cardiol
. 2021 Jul;
341:24-30.
PMID: 34265313
Background: Novel therapies that can limit or reverse damage caused by myocardial infarction (MI) could ease the increasing burden of heart failure. In this regard Platelet Derived Growth Factor (PDGF)...
10.