Jose M Mates
Overview
Explore the profile of Jose M Mates including associated specialties, affiliations and a list of published articles.
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45
Citations
2670
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Recent Articles
1.
De Los Santos-Jimenez J, Campos-Sandoval J, Rosales T, Ko B, Alonso F, Marquez J, et al.
Int J Mol Sci
. 2025 Jan;
26(1.
PMID: 39796278
Glutaminase controls the first step in glutaminolysis, impacting bioenergetics, biosynthesis and oxidative stress. Two isoenzymes exist in humans, GLS and GLS2. GLS is considered prooncogenic and overexpressed in many tumours,...
2.
De Los Santos-Jimenez J, Campos-Sandoval J, Alonso F, Marquez J, Mates J
Antioxidants (Basel)
. 2024 Jun;
13(6).
PMID: 38929183
A pathway frequently altered in cancer is glutaminolysis, whereby glutaminase (GA) catalyzes the main step as follows: the deamidation of glutamine to form glutamate and ammonium. There are two types...
3.
De Los Santos-Jimenez J, Rosales T, Ko B, Campos-Sandoval J, Alonso F, Marquez J, et al.
Cancers (Basel)
. 2023 Jan;
15(2).
PMID: 36672480
Most tumor cells can use glutamine (Gln) for energy generation and biosynthetic purposes. Glutaminases (GAs) convert Gln into glutamate and ammonium. In humans, GAs are encoded by two genes: and...
4.
Campos-Sandoval J, Gomez-Garcia M, De Los Santos-Jimenez J, Mates J, Alonso F, Marquez J
Neurochem Int
. 2021 Jul;
149:105136.
PMID: 34274381
Glioblastoma remains one of the most challenging and devastating cancers, with only a very small proportion of patients achieving 5-year survival. The current standard of care consists of surgery, followed...
5.
De Los Santos-Jimenez J, Campos-Sandoval J, Marquez-Torres C, Urbano-Polo N, Brondegaard D, Martin-Rufian M, et al.
J Biomed Sci
. 2021 Feb;
28(1):14.
PMID: 33610185
Background: Glutaminase isoenzymes GLS and GLS2 play apparently opposing roles in cancer: GLS acts as an oncoprotein, while GLS2 (GAB isoform) has context specific tumour suppressive activity. Some microRNAs (miRNAs)...
6.
Marquez J, Mates J
Cancers (Basel)
. 2021 Jan;
13(2).
PMID: 33467031
The study of cancer metabolism is regaining center stage and becoming a hot topic in tumor biology and clinical research, after a period where such kind of experimental approaches were...
7.
Lopez de la Oliva A, Campos-Sandoval J, Gomez-Garcia M, Cardona C, Martin-Rufian M, Sialana F, et al.
Sci Rep
. 2021 Jan;
11(1):249.
PMID: 33397990
No abstract available.
8.
Mates J, Campos-Sandoval J, De Los Santos-Jimenez J, Marquez J
Arch Toxicol
. 2020 Jul;
94(8):2603-2623.
PMID: 32681190
Targeted therapies against cancer have improved both survival and quality of life of patients. However, metabolic rewiring evokes cellular mechanisms that reduce therapeutic mightiness. Resistant cells generate more glutathione, elicit...
9.
Lopez de la Oliva A, Campos-Sandoval J, Gomez-Garcia M, Cardona C, Martin-Rufian M, Sialana F, et al.
Sci Rep
. 2020 Feb;
10(1):2259.
PMID: 32042057
Glutaminase (GA) catalyzes the first step in mitochondrial glutaminolysis playing a key role in cancer metabolic reprogramming. Humans express two types of GA isoforms: GLS and GLS2. GLS isozymes have...
10.
Ramirez-Pena E, Arnold J, Shivakumar V, Joseph R, Vidhya Vijay G, den Hollander P, et al.
Cancers (Basel)
. 2019 Oct;
11(10).
PMID: 31652551
Identifying bioenergetics that facilitate the epithelial to mesenchymal transition (EMT) in breast cancer cells may uncover targets to treat incurable metastatic disease. Metastasis is the number one cause of cancer-related...