Jose M Lora
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Explore the profile of Jose M Lora including associated specialties, affiliations and a list of published articles.
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28
Citations
2267
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Recent Articles
1.
Sanmarco L, Rone J, Polonio C, Lahore G, Giovannoni F, Ferrara K, et al.
Nature
. 2023 Aug;
620(7975):881-889.
PMID: 37558878
Dendritic cells (DCs) have a role in the development and activation of self-reactive pathogenic T cells. Genetic variants that are associated with the function of DCs have been linked to...
2.
Sanmarco L, Rone J, Polonio C, Giovannoni F, Lahore G, Ferrara K, et al.
bioRxiv
. 2023 Mar;
PMID: 36993446
Dendritic cells (DCs) control the generation of self-reactive pathogenic T cells. Thus, DCs are considered attractive therapeutic targets for autoimmune diseases. Using single-cell and bulk transcriptional and metabolic analyses in...
3.
Cable J, Leonard J, Lu T, Xie Z, Chang M, Fernandez L, et al.
Ann N Y Acad Sci
. 2021 Nov;
1506(1):98-117.
PMID: 34786712
Synthetic biology has the potential to transform cell- and gene-based therapies for a variety of diseases. Sophisticated tools are now available for both eukaryotic and prokaryotic cells to engineer cells...
4.
Canale F, Basso C, Antonini G, Perotti M, Li N, Sokolovska A, et al.
Nature
. 2021 Oct;
598(7882):662-666.
PMID: 34616044
The availability of L-arginine in tumours is a key determinant of an efficient anti-tumour T cell response. Consequently, increases of typically low L-arginine concentrations within the tumour may greatly potentiate...
5.
Cubillos-Ruiz A, Guo T, Sokolovska A, Miller P, Collins J, Lu T, et al.
Nat Rev Drug Discov
. 2021 Oct;
20(12):941-960.
PMID: 34616030
The steadfast advance of the synthetic biology field has enabled scientists to use genetically engineered cells, instead of small molecules or biologics, as the basis for the development of novel...
6.
Leventhal D, Sokolovska A, Li N, Plescia C, Kolodziej S, Gallant C, et al.
Nat Commun
. 2020 Jun;
11(1):2739.
PMID: 32483165
Synthetic biology is a powerful tool to create therapeutics which can be rationally designed to enable unique and combinatorial functionalities. Here we utilize non-pathogenic E coli Nissle as a versatile...
7.
Manni M, Mandalapu S, Salmeron A, Lora J, Kolls J, Alcorn J
Sci Rep
. 2017 Feb;
7:43139.
PMID: 28233801
Atopic asthma is a prevalent respiratory disease that is characterized by inflammation, mucus hypersecretion, and airway hyperresponsiveness. The complexity of this heterogeneous disorder has commanded the need to better define...
8.
Ghosh S, Lora J
Drug Discov Today Technol
. 2016 Oct;
19:39-44.
PMID: 27769356
Epigenetic control of gene expression is enforced in part through histone modifications. Bromodomain and extra terminal domain (BET) proteins function as crucial chromatin readers, responsible for interpretation of the chromatin...
9.
Chen K, Campfield B, Wenzel S, McAleer J, Kreindler J, Kurland G, et al.
JCI Insight
. 2016 Aug;
1(11).
PMID: 27517095
Significant morbidity in cystic fibrosis (CF) results from chronic lung inflammation, most commonly due to infection. Recent data suggest that IL-17 contributes to pathological inflammation in the setting of abnormal...
10.
Ghosh S, Taylor A, Chin M, Huang H, Conery A, Mertz J, et al.
J Biol Chem
. 2016 Apr;
291(25):13014-27.
PMID: 27056325
Covalent modification of histones is a fundamental mechanism of regulated gene expression in eukaryotes, and interpretation of histone modifications is an essential feature of epigenetic control. Bromodomains are specialized binding...