Jose F Fierro
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Explore the profile of Jose F Fierro including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
209
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Recent Articles
1.
Andres M, Yount N, Acosta-Zaldivar M, Yeaman M, Fierro J
Int J Mol Sci
. 2024 Sep;
25(17).
PMID: 39273619
Human lactoferrin (hLf) is an innate host defense protein that inhibits microbial H-ATPases. This protein includes an ancestral structural motif (i.e., γ-core motif) intimately associated with the antimicrobial activity of...
2.
Andres M, Fierro P, Antuna V, Fierro J
Int J Mol Sci
. 2024 Jul;
25(13).
PMID: 39000442
Human defensins are cysteine-rich peptides (Cys-rich peptides) of the innate immune system. Defensins contain an ancestral structural motif (i.e., γ-core motif) associated with the antimicrobial activity of natural Cys-rich peptides....
3.
Qi W, Acosta-Zaldivar M, Flanagan P, Liu N, Jani N, Fierro J, et al.
PLoS Pathog
. 2022 Jun;
18(6):e1010089.
PMID: 35687592
Whether to commit limited cellular resources toward growth and proliferation, or toward survival and stress responses, is an essential determination made by Target of Rapamycin Complex 1 (TORC1) for a...
4.
Santos-Pereira C, Andres M, Fierro J, Rodrigues L, Corte-Real M
Int J Biol Macromol
. 2022 Jan;
202:309-317.
PMID: 35038474
Lactoferrin (Lf) is a versatile natural milk-derived protein that exhibits multiple interesting biological activities. Since it is safe for human administration and currently manufactured using low cost and well-established large-scale...
5.
Santos-Pereira C, Andres M, Chaves S, Fierro J, Geros H, Manon S, et al.
Int J Biol Macromol
. 2021 Jan;
171:343-357.
PMID: 33421469
Lactoferrin (Lf) is a bioactive milk-derived protein with remarkable wide-spectrum antifungal activity. To deepen our understanding of the molecular mechanisms underlying Lf cytotoxicity, the role of plasma membrane ergosterol- and...
6.
Andres M, Acosta-Zaldivar M, Gonzalez-Seisdedos J, Fierro J
Int J Mol Sci
. 2019 Nov;
20(23).
PMID: 31757076
In yeast, we reported the critical role of K-efflux for the progress of the regulated cell death (RCD) induced by human lactoferrin (hLf), an antimicrobial protein of the innate immune...
7.
Andres M, Acosta-Zaldivar M, Fierro J
Antimicrob Agents Chemother
. 2016 May;
60(7):4206-16.
PMID: 27139463
Human lactoferrin (hLf) is a protein of the innate immune system which induces an apoptotic-like process in yeast. Determination of the susceptibility to lactoferrin of several yeast species under different...
8.
Andres M, Fierro J
Antimicrob Agents Chemother
. 2010 Jul;
54(10):4335-42.
PMID: 20625147
Two bacterial species with different metabolic features, namely, Pseudomonas aeruginosa and Lactococcus lactis, were used as a comparative experimental model to investigate the antimicrobial target and mechanism of transferrins. In...
9.
Andres M, Viejo-Diaz M, Fierro J
Antimicrob Agents Chemother
. 2008 Aug;
52(11):4081-8.
PMID: 18710913
Human lactoferrin (hLf) induced an apoptosis-like phenotype in Candida albicans cells, which includes phosphatidylserine externalization, nuclear chromatin condensation, DNA degradation, and increased reactive oxygen species (ROS) production. Intracellular ROS accumulation...
10.
Yount N, Andres M, Fierro J, Yeaman M
Biochim Biophys Acta
. 2007 Oct;
1768(11):2862-72.
PMID: 17916323
Kaliocin-1 is a 31-residue peptide derived from human lactoferrin, and with antimicrobial properties that recapitulate those of its 611 amino acid parent holoprotein. As kaliocin-1 is a cysteine-stabilized peptide, it...