Joris Messens
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Explore the profile of Joris Messens including associated specialties, affiliations and a list of published articles.
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117
Citations
2535
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Recent Articles
1.
Zhang W, Van den Bossche W, Yagoubi H, Kambale E, Wahni K, Saxena T, et al.
Adv Healthc Mater
. 2025 Feb;
:e2403497.
PMID: 39905897
Glucagon-like peptide 2 (GLP-2) stimulates intestinal growth, repairs mucosa, and enhances epithelial integrity but has a short half-life (7 min). Glepaglutide (GL), a GLP-2 analog with an extended half-life (50 ...
2.
Dechenne J, Wierzbicka M, Krimou R, El Aakchioui A, Malo Pueyo J, Messens J, et al.
J Med Chem
. 2025 Jan;
68(2):1433-1445.
PMID: 39748145
Arginase-1 (ARG-1) is a promising target for cancer immunotherapy, but the small size and the highly polar nature of its catalytic site present significant challenges for inhibitor development. An alternative...
3.
De Smet B, Yang X, Plskova Z, Castell C, Fernandez-Fernandez A, Dard A, et al.
J Exp Bot
. 2024 Dec;
PMID: 39726278
In aerobic life forms, reactive oxygen species (ROS) are produced by the partial reduction of oxygen during energy-generating metabolic processes. In plants, ROS production increases during periods of both abiotic...
4.
Scherschel M, Niemeier J, Jacobs L, Hoffmann M, Diederich A, Bell C, et al.
Nat Commun
. 2024 Dec;
15(1):10704.
PMID: 39702652
The NADPH/NADP redox couple is central to metabolism and redox signalling. NADP redox state is differentially regulated by distinct enzymatic machineries at the subcellular compartment level. Nonetheless, a detailed understanding...
5.
Perez-Chavez I, Koberstein J, Malo Pueyo J, Gilglioni E, Vertommen D, Baeyens N, et al.
iScience
. 2024 Dec;
27(12):111336.
PMID: 39640569
HYlight is a genetically encoded fluorescent biosensor that ratiometrically monitors fructose 1,6-bisphosphate (FBP), a key glycolytic metabolite. Given the role of glucose in liver cancer metabolism, we expressed HYlight in...
6.
Gilglioni E, Li A, St-Pierre-Wijckmans W, Shen T, Perez-Chavez I, Hovhannisyan G, et al.
Nat Commun
. 2024 Nov;
15(1):9522.
PMID: 39496584
Fat accumulation, de novo lipogenesis, and glycolysis are key drivers of hepatocyte reprogramming and the consequent metabolic dysfunction-associated steatotic liver disease (MASLD). Here we report that obesity leads to dysregulated...
7.
Caccamo A, Lazzarotto F, Margis-Pinheiro M, Messens J, Remacle C
Front Plant Sci
. 2024 Oct;
15:1487328.
PMID: 39445148
We review the newly classified ascorbate peroxidase-related (APX-R) proteins, which do not use ascorbate as electron donor to scavenge HO. We summarize recent discoveries on the function and the characterization...
8.
Shen J, Song X, Bickel D, Rosen B, Zhao F, Messens J, et al.
Mol Microbiol
. 2024 Jun;
122(2):201-212.
PMID: 38922722
An arsenate reductase (Car1) from the Bacteroidetes species Rufibacter tibetensis 1351 was isolated from the Tibetan Plateau. The strain exhibits resistance to arsenite [As(III)] and arsenate [As(V)] and reduces As(V)...
9.
Deskeuvre M, Lan J, Messens J, Riant O, Feron O, Frederick R
Int J Pharm
. 2024 Apr;
657:124132.
PMID: 38641019
Targeting enzymes involved in lipid metabolism is increasingly recognized as a promising anticancer strategy. Efficient inhibition of diacylglycerol O-transferase 1 (DGAT1) can block fatty acid (FA) storage. This, in turn,...
10.
Caccamo A, Vega de Luna F, Misztak A, Pyr Dit Ruys S, Vertommen D, Cardol P, et al.
Plant Cell Physiol
. 2024 Apr;
65(4):644-656.
PMID: 38591346
The function of ascorbate peroxidase-related (APX-R) proteins, present in all green photosynthetic eukaryotes, remains unclear. This study focuses on APX-R from Chlamydomonas reinhardtii, namely, ascorbate peroxidase 2 (APX2). We showed...