Jorge Pedrosa
Overview
Explore the profile of Jorge Pedrosa including associated specialties, affiliations and a list of published articles.
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Articles
64
Citations
1596
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Recent Articles
1.
Coelho-Ribeiro B, Silva H, Sampaio-Marques B, Fraga A, Azevedo O, Pedrosa J, et al.
Cells
. 2024 Apr;
13(8.
PMID: 38667269
Fabry Disease (FD) is one of the most prevalent lysosomal storage disorders, resulting from mutations in the gene located on the X chromosome. This genetic mutation triggers glo-botriaosylceramide (Gb-3) buildup...
2.
Correia C, Leite A, Fraga A, Proenca M, Pedrosa J, Carvalho M
Eur J Med Chem
. 2024 Mar;
268:116297.
PMID: 38458108
A series of novel 9-alkyl/aryl-2-aryl-6-carbamoylpurines were synthesized, and their activity against Mycobacterium tuberculosis strain HRv was assessed. The SAR analysis on the first set of derivatives, with an alkyl or...
3.
Dominguez J, Mendes A, Pacheco A, Peixoto M, Pedrosa J, Fraga A
Front Microbiol
. 2023 Oct;
14:1266261.
PMID: 37840746
causes Buruli Ulcer, a neglected infectious skin disease that typically progresses from an early non-ulcerative lesion to an ulcer with undermined edges. If not promptly treated, these lesions can lead...
4.
Azarias Da Silva M, Nioche P, Soudaramourty C, Bull-Maurer A, Tiouajni M, Kong D, et al.
Sci Adv
. 2023 Aug;
9(31):eadg2122.
PMID: 37540749
Since the initial spread of severe acute respiratory syndrome coronavirus 2 infection, several viral variants have emerged and represent a major challenge for immune control, particularly in the context of...
5.
Mendes A, Fraga A, Peixoto M, Aroso I, Longatto-Filho A, Marques A, et al.
Bioeng Transl Med
. 2023 May;
8(3):e10504.
PMID: 37206216
Diabetic foot infection (DFI) is an important cause of morbidity and mortality. Antibiotics are fundamental for treating DFI, although bacterial biofilm formation and associated pathophysiology can reduce their effectiveness. Additionally,...
6.
Santa Cruz A, Mendes-Frias A, Azarias-da-Silva M, Andre S, Oliveira A, Pires O, et al.
Nat Commun
. 2023 Mar;
14(1):1772.
PMID: 36997530
Several millions of individuals are estimated to develop post-acute sequelae SARS-CoV-2 condition (PASC) that persists for months after infection. Here we evaluate the immune response in convalescent individuals with PASC...
7.
Mendes A, Peixoto M, Marques A, Pedrosa J, Fraga A
BMC Res Notes
. 2022 Sep;
15(1):293.
PMID: 36071445
Objective: Diabetic foot infection (DFI) represents a major healthcare burden, for which treatment is challenging owing to the pathophysiological alterations intrinsic to diabetes and the alarming increase of antimicrobial resistance....
8.
Andre S, Azarias Da Silva M, Picard M, Alleaume-Buteau A, Kundura L, Cezar R, et al.
Cell Death Dis
. 2022 Aug;
13(8):741.
PMID: 36030261
In addition to an inflammatory reaction, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-infected patients present lymphopenia, which we recently reported as being related to abnormal programmed cell death. As an...
9.
Mendes A, Rebelo R, Aroso I, Correlo V, Fraga A, Pedrosa J, et al.
Int J Pharm
. 2022 Jun;
623:121954.
PMID: 35760261
Skin infection by Mycobacterium ulcerans causes Buruli ulcer (BU) disease, a serious condition that significantly impact patient' health and quality of life and can be very difficult to treat. Treatment...
10.
Andre S, Picard M, Cezar R, Roux-Dalvai F, Alleaume-Butaux A, Soundaramourty C, et al.
Cell Death Differ
. 2022 Jan;
29(8):1486-1499.
PMID: 35066575
Severe SARS-CoV-2 infections are characterized by lymphopenia, but the mechanisms involved are still elusive. Based on our knowledge of HIV pathophysiology, we hypothesized that SARS-CoV-2 infection-mediated lymphopenia could also be...