Jorge Filmus
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Explore the profile of Jorge Filmus including associated specialties, affiliations and a list of published articles.
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Articles
47
Citations
2316
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Recent Articles
1.
Mead T, Bhutada S, Foulcer S, Peruzzi N, Nelson C, Seifert D, et al.
Matrix Biol
. 2024 May;
131:1-16.
PMID: 38750698
Extracellular matrix remodeling mechanisms are understudied in cardiac development and congenital heart defects. We show that matrix-degrading metalloproteases ADAMTS1 and ADAMTS5, are extensively co-expressed during mouse cardiac development. The mouse...
2.
Stigliano I, Puricelli L, Filmus J, Sogayar M, Bal De Kier Joffe E, Peters M
Breast Cancer Res Treat
. 2023 Sep;
203(1):185.
PMID: 37688668
No abstract available.
3.
Crenshaw M, Meyers M, Brown K, Slegesky V, Duis J, Elias E, et al.
Am J Med Genet A
. 2023 Jun;
191(10):2571-2577.
PMID: 37353964
Skeletal dysplasias broadly include disorders of cartilage or bone. Omodysplasia-1 is a type of skeletal dysplasia caused by biallelic loss of function variants in the GPC6 gene. GPC6 codes for...
4.
Shi W, Filmus J
Dev Dyn
. 2022 Sep;
251(12):2015-2028.
PMID: 36057966
Background: Glypicans are a family of proteoglycans that play important roles in embryonic morphogenesis. The mammalian genome contains six glypicans (GPC1 to GPC6). GPC6 and GPC4 are the pair of...
5.
Filmus J
Am J Physiol Cell Physiol
. 2022 Mar;
322(4):C694-C698.
PMID: 35235423
Glypicans are proteoglycans that are bound to the outer surface of the plasma membrane by a glycosylphosphatidylinositol anchor. The mammalian genome contains six members of the glypican family ( to...
6.
Wang W, Han N, Xu Y, Zhao Y, Shi L, Filmus J, et al.
Nat Commun
. 2020 Nov;
11(1):5915.
PMID: 33219207
Proteoglycans (PGs) are composed of a core protein and one or more chains of glycosaminoglycans (GAGs). The highly heterogeneous GAG chains play an irreplaceable role in the functions of PGs....
7.
Shi W, Kaneiwa T, Cydzik M, Gariepy J, Filmus J
Matrix Biol
. 2019 Nov;
88:19-32.
PMID: 31756413
We report here that Glypican-6 (GPC6)-null mice display at birth small intestines that are 75% shorter than those of normal littermates. Notably, we demonstrate that the role of GPC6 in...
8.
Liu T, Xia L, Yao Y, Yan C, Fan Y, Gajendran B, et al.
Cell Death Dis
. 2019 Feb;
10(2):117.
PMID: 30741932
The ETS transcription factor Fli-1 controls the expression of genes involved in hematopoiesis including cell proliferation, survival, and differentiation. Dysregulation of Fli-1 induces hematopoietic and solid tumors, rendering it an...
9.
Song J, Yuan C, Yang J, Liu T, Yao Y, Xiao X, et al.
FEBS J
. 2018 Nov;
285(24):4631-4645.
PMID: 30387554
E26 transformation-specific (ETS) gene family contains a common DNA-binding domain, the ETS domain, responsible for sequence-specific DNA recognition on target promoters. The Fli-1 oncogene, a member of ETS gene family,...
10.
Capurro M, Izumikawa T, Suarez P, Shi W, Cydzik M, Kaneiwa T, et al.
J Cell Biol
. 2017 Jul;
216(9):2911-2926.
PMID: 28696225
Autosomal-recessive omodysplasia (OMOD1) is a genetic condition characterized by short stature, shortened limbs, and facial dysmorphism. OMOD1 is caused by loss-of-function mutations of glypican 6 (). In this study, we...