Jorg Leers
Overview
Explore the profile of Jorg Leers including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
154
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0
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Recent Articles
1.
Diegmuller F, Leers J, Hake S
J Biol Chem
. 2025 Jan;
301(2):108154.
PMID: 39761855
In 2023, the brilliant chromatin biologist C. David Allis passed away leaving a large void in the scientific community and broken hearts in his family and friends. With this review,...
2.
Wunderlich T, Deshpande C, Paasche L, Friedrich T, Diegmuller F, Haddad E, et al.
Nucleic Acids Res
. 2024 Oct;
52(21):12831-12849.
PMID: 39460621
The evolutionarily conserved histone variant H2A.Z plays a crucial role in various DNA-based processes, but the mechanisms underlying its activity are not completely understood. Recently, we identified the zinc finger...
3.
Herchenrother A, Gossen S, Friedrich T, Reim A, Daus N, Diegmuller F, et al.
Nat Commun
. 2023 Jan;
14(1):472.
PMID: 36709316
Specialized chromatin-binding proteins are required for DNA-based processes during development. We recently established PWWP2A as a direct histone variant H2A.Z interactor involved in mitosis and craniofacial development. Here, we identify...
4.
Harke N, Leers J, Kietz S, Drenckhahn D, Forster C
Mol Cell Endocrinol
. 2008 Sep;
295(1-2):39-47.
PMID: 18782596
The 65kDa protein occludin is an essential element of the blood-brain barrier. This integral membrane protein represents an important part of the tight junctions, which seal and protect the blood...
5.
Forster C, Waschke J, Burek M, Leers J, Drenckhahn D
J Physiol
. 2006 Mar;
573(Pt 2):413-25.
PMID: 16543270
Endothelial cells (ECs) from different vascular beds display certain common qualities, but each subtype is uniquely adapted to meet the demands of the underlying tissues. The structural peculiarities of intercellular...
6.
Brackertz M, Gong Z, Leers J, Renkawitz R
Nucleic Acids Res
. 2006 Jan;
34(2):397-406.
PMID: 16415179
The Mi-2/NuRD complex is a multi-subunit protein complex with enzymatic activities involving chromatin remodeling and histone deacetylation. Targeting of Mi-2/NuRD to methylated CpG sequences mediates gene repression. The function of...
7.
Matthews J, Almlof T, Kietz S, Leers J, Gustafsson J
Biochem Biophys Res Commun
. 2005 Aug;
335(1):168-74.
PMID: 16055089
The suppressor of cytokine signalling (SOCS) protein family negatively regulates cytokine action. In this study, we investigated the effects of estrogen (E2) on SOCS-3 expression in T47D and MCF-7 human...
8.
Bull A, Steffensen K, Leers J, Rafter J
Carcinogenesis
. 2003 Sep;
24(11):1717-22.
PMID: 12949056
The nuclear hormone receptor peroxisome proliferator-activated receptor (PPAR) gamma plays an important role in the differentiation of intestinal cells and other tissues. Real-time PCR examination of PPAR mRNA for gamma1,...