Jorg Isensee
Overview
Explore the profile of Jorg Isensee including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
813
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Recent Articles
1.
Pinheiro-Junior E, Alirahimi E, Peigneur S, Isensee J, Schiffmann S, Erkoc P, et al.
BMC Biol
. 2024 Jul;
22(1):164.
PMID: 39075558
Background: The identification of novel toxins from overlooked and taxonomically exceptional species bears potential for various pharmacological applications. The remipede Xibalbanus tulumensis, an underwater cave-dwelling crustacean, is the only crustacean...
2.
Klein I, Isensee J, Wiesen M, Imhof T, Wassermann M, Muller C, et al.
Cells
. 2023 May;
12(9).
PMID: 37174648
Peripheral neuropathy is a common side effect of cancer treatment with paclitaxel. The mechanisms by which paclitaxel is transported into neurons, which are essential for preventing neuropathy, are not well...
3.
Roderer P, Belu A, Heidrich L, Siobal M, Isensee J, Prolingheuer J, et al.
Pain
. 2023 Feb;
164(8):1718-1733.
PMID: 36727909
Induced pluripotent stem cells (iPSCs) have enabled the generation of various difficult-to-access cell types such as human nociceptors. A key challenge associated with human iPSC-derived nociceptors (hiPSCdNs) is their prolonged...
4.
Ratz L, Brambillasca C, Bartke L, Huetzen M, Goergens J, Leidecker O, et al.
Breast Cancer Res
. 2022 Jun;
24(1):41.
PMID: 35715861
Background: The majority of BRCA1-mutant breast cancers are characterized by a triple-negative phenotype and a basal-like molecular subtype, associated with aggressive clinical behavior. Current treatment options are limited, highlighting the...
5.
Yang N, Isensee J, Neel D, Quadros A, Zhang H, Lauzadis J, et al.
Nat Neurosci
. 2021 Dec;
25(2):168-179.
PMID: 34931070
Bacterial products can act on neurons to alter signaling and function. In the present study, we found that dorsal root ganglion (DRG) sensory neurons are enriched for ANTXR2, the high-affinity...
6.
Cai S, Moutal A, Yu J, Chew L, Isensee J, Chawla R, et al.
Sci Transl Med
. 2021 Nov;
13(619):eabh1314.
PMID: 34757807
The voltage-gated sodium NaV1.7 channel, critical for sensing pain, has been actively targeted by drug developers; however, there are currently no effective and safe therapies targeting NaV1.7. Here, we tested...
7.
Schmidt J, Goergens J, Pochechueva T, Kotter A, Schwenzer N, Sitte M, et al.
Hum Genet
. 2021 Sep;
140(12):1679-1693.
PMID: 34545459
The highly conserved YrdC domain-containing protein (YRDC) interacts with the well-described KEOPS complex, regulating specific tRNA modifications to ensure accurate protein synthesis. Previous studies have linked the KEOPS complex to...
8.
Isensee J, van Cann M, Despang P, Araldi D, Moeller K, Petersen J, et al.
J Cell Biol
. 2021 Aug;
220(10).
PMID: 34431981
Depolarization drives neuronal plasticity. However, whether depolarization drives sensitization of peripheral nociceptive neurons remains elusive. By high-content screening (HCS) microscopy, we revealed that depolarization of cultured sensory neurons rapidly activates...
9.
Kanne J, Hussong M, Isensee J, Munoz-Lopez A, Wolffgramm J, Hess F, et al.
Cell Death Dis
. 2021 May;
12(6):530.
PMID: 34031359
Non-coding RNA from pericentromeric satellite repeats are involved in stress-dependent splicing processes, maintenance of heterochromatin, and are required to protect genome stability. Here we show that the long non-coding satellite...
10.
van Cann M, Kuzmenkov A, Isensee J, Andreev-Andrievskiy A, Peigneur S, Khusainov G, et al.
FEBS J
. 2020 Oct;
288(7):2418-2435.
PMID: 33051988
Venoms are a rich source of highly specific toxins, which allow the identification of novel therapeutic targets. We have now applied high content screening (HCS) microscopy to identify toxins that...