Joon Hee Hong
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Explore the profile of Joon Hee Hong including associated specialties, affiliations and a list of published articles.
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91
Citations
36
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Recent Articles
1.
Hong J
Curr Med Chem
. 2024 May;
PMID: 38693731
Nucleotide analogs known as acyclic and cyclic nucleoside phosphonates (ANPs and CNPs, respectively) have a variety of biological properties, including antibacterial, antiviral, antiparasitic, antineoplastic, and immunomodulatory. A strong reaction that...
2.
Shen G, Hong J
Carbohydr Res
. 2022 Feb;
513:108517.
PMID: 35152128
The synthesis of five series of 4'-truncated nucleoside phosphonic acid analogues is discussed in this review: (1) 4'-truncated furanose nucleoside phosphonic acid analogues; (2) 4'-truncated pyrrolidine nucleoside phosphonic acid analogues;...
3.
Shen G, Hong J
Curr Med Chem
. 2021 Nov;
29(22):3857-3921.
PMID: 34766884
The present review focuses on the synthesis of cyclic 5'-deoxynucleoside phosphonate analogs. The formation of various phosphonate alkyl moieties is accomplished through (i) Wittig (or HWE) type condensation to the...
4.
Shen G, Hong J
Curr Med Chem
. 2019 Jun;
27(35):5918-5948.
PMID: 31250746
The syntheses of acyclic nucleoside phosphonate (ANP) analogs linked with cyclic systems are described in the present review. The purpose of the review is to report the methodology of ANP...
5.
Shen G, Hong J
Carbohydr Res
. 2018 May;
463:47-106.
PMID: 29772449
Nucleoside phosphonates are isosteric, isopolar, and isoelectronic with phosphates. Nucleoside phosphonates can undergo enzymatic phosphorylation for conversion into the corresponding diphosphoryl phosphonates, which are naturally occurring nucleoside triphosphate analogues. The...
6.
Kim E, Hong J
Nucleosides Nucleotides Nucleic Acids
. 2016 Feb;
35(3):130-46.
PMID: 26855237
Racemic synthesis of novel 2',5',5'-trifluoro-apiose nucleoside phosphonic acid analogs were performed as potent antiviral agents. Phosphonation was performed by direct displacement of triflate intermediate with diethyl (lithiodifluoromethyl) phosphonate to give...
7.
Kim S, Hong J
Nucleosides Nucleotides Nucleic Acids
. 2016 Jan;
35(2):83-103.
PMID: 26822717
As antiviral nucleosides containing a fluorine atom at 2'-position are endowed with increased stabilization of glycosyl bond, it was of interest to investigate the influence of three fluorine atoms at...
8.
Kim S, Hong J
Nucleosides Nucleotides Nucleic Acids
. 2015 Oct;
34(10):708-28.
PMID: 26467263
The first synthetic route to 5'-deoxy-6',6'-difluoro-carbocyclic C-nucleoside [9-deazaadenosine, (pyrrolo[3,2-d]pyrimidine)] phosphonic acids from commercially available epichlorohydrin 5 was described. The key C-C bond formation from cyclopentanone to base precursor was performed...
9.
Kim S, Hong J
Nucleosides Nucleotides Nucleic Acids
. 2015 Sep;
34(12):815-33.
PMID: 26407633
Novel 2'-deoxy-2'-β-fluoro-threose purine phosphonic acid analogues were designed and racemically synthesized from 2-propanone-1,3-diacetate. Condensation successfully proceeded from a glycosyl donor 9 under Vorbrüggen conditions. Cross-metathesis of vinyl analogues 13 and...
10.
Kim E, Hong J
Nucleosides Nucleotides Nucleic Acids
. 2015 Sep;
34(11):737-52.
PMID: 26398671
The first synthetic route to 5'-deoxycarbocyclic C-nucleoside [9-deazaadenosine, (pyrrolo[3,2-d]pyrimidine)] phosphonic acids from commercially available 1,4-dihydroxy-2-butene was described. The key C-C bond formation from cyclopentanone to base precursor was performed using...