Joni Leppanen
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Explore the profile of Joni Leppanen including associated specialties, affiliations and a list of published articles.
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12
Citations
213
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Recent Articles
1.
Kemi N, Hiltunen N, Vayrynen J, Pohjanen V, Helminen O, Junttila A, et al.
Cancers (Basel)
. 2020 Dec;
12(12).
PMID: 33276550
Purpose: To examine and compare the prognostic value of immune cell score (ICS) and Klintrup-Mäkinen (KM) grade in gastric cancer. Methods: Gastric adenocarcinoma tissues from samples of 741 patients surgically...
2.
Kaisti M, Panula T, Leppanen J, Punkkinen R, Jafari Tadi M, Vasankari T, et al.
NPJ Digit Med
. 2019 Jul;
2:39.
PMID: 31304385
There is an unmet clinical need for a low cost and easy to use wearable devices for continuous cardiovascular health monitoring. A flexible and wearable wristband, based on microelectromechanical sensor...
3.
Tahkola K, Leppanen J, Ahtiainen M, Vayrynen J, Haapasaari K, Karttunen T, et al.
Virchows Arch
. 2019 Mar;
474(6):691-699.
PMID: 30843106
An immune cell score (ICS) was introduced for predicting survival in pancreatic ductal adenocarcinoma (PDAC). Few studies have compared different methods of evaluating immune infiltrate. This study compared ICSs determined...
4.
Leppanen J, Lindholm V, Isohookana J, Haapasaari K, Karihtala P, Lehenkari P, et al.
Pancreas
. 2018 Nov;
48(1):43-48.
PMID: 30451798
Objectives: Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant stroma with increased expression of tenascin C and fibronectin. Their role and tumor-stroma ratio in PDAC are not well known. The...
5.
Leppanen J, Helminen O, Huhta H, Kauppila J, Isohookana J, Haapasaari K, et al.
APMIS
. 2018 Oct;
126(11):852-863.
PMID: 30357962
Pancreatic cancer arises from precursor lesions called pancreatic intraepithelial neoplasia (PanIN) characterized by inflammatory microenvironment. In pancreatic cancer, strong innate immunity and hypoxia responses are typical. Occurrence and relationship of...
6.
Kemi N, Eskuri M, Herva A, Leppanen J, Huhta H, Helminen O, et al.
Br J Cancer
. 2018 Jul;
119(4):435-439.
PMID: 30057407
Background: Tumour microenvironment, including tumour-stroma ratio (TSR), might help identifying high-risk cancer patients. However, the significance of TSR in gastric cancer is unclear, especially in the intestinal and diffuse subtypes....
7.
Leppanen J, Helminen O, Huhta H, Kauppila J, Isohookana J, Haapasaari K, et al.
World J Surg Oncol
. 2018 Jul;
16(1):127.
PMID: 29973215
Background: HIF-1alpha and CAIX proteins are commonly expressed under hypoxic conditions, but other regulatory factors have been described as well. Pancreatic ductal adenocarcinoma (PDAC) is characterized by hypoxia and strong...
8.
Isohookana J, Haapasaari K, Soini Y, Leppanen J, Karihtala P
Pathol Res Pract
. 2018 May;
214(6):840-847.
PMID: 29735403
Background: We studied the expression of some major proteins involved in cell-cycle regulation and DNA repair, the roles of which are not well known in pancreatic ductal adenocarcinoma (PDAC), but...
9.
Leppanen J, Bogdanoff S, Lehenkari P, Saarnio J, Kauppila J, Karttunen T, et al.
Oncotarget
. 2017 Oct;
8(40):66865-66877.
PMID: 28978001
Background: Tenascin-C and fibronectin are adhesive glycoproteins modulating the structure of the extracellular matrix and cellular functions. Their expression and function in esophageal adenocarcinoma is poorly known. The aim of...
10.
Leppanen J, Helminen O, Huhta H, Kauppila J, Isohookana J, Haapasaari K, et al.
Virchows Arch
. 2017 Feb;
470(4):401-410.
PMID: 28191612
Pancreatic cancer remains one of the deadliest malignancies in the world. Inflammatory response and tumor environment are thought to play a major role in its pathogenesis. Knowledge on TLR expression...