Immune Cell Infiltrate and Prognosis in Gastric Cancer

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2020 Dec 5

PMID 33276550

Citations 10

Authors

Niko Kemi

Niko Hiltunen

Juha P Vayrynen

Vesa-Matti Pohjanen

Olli Helminen

Anna Junttila

Johanna Mrena

Jan Bohm

Heikki Huhta

Joni Leppanen

Tuomo J Karttunen

Joonas H Kauppila

Affiliations

Soon will be listed here.

Abstract

Purpose: To examine and compare the prognostic value of immune cell score (ICS) and Klintrup-Mäkinen (KM) grade in gastric cancer.

Methods: Gastric adenocarcinoma tissues from samples of 741 patients surgically treated in two hospitals in Finland were assessed for ICS and KM grade. Cox regression with adjustment for confounders provided hazard ratios (HRs) and 95% CIs. Subgroup analyses were performed in intestinal and diffuse type subgroups. The primary outcome was 5-year overall survival.

Results: High ICS was associated to longer 5-year survival (adjusted HR 0.70, 95% CI 0.52-0.94), compared to low ICS. The difference was significant in intestinal type subgroup (adjusted HR 0.54, 95% CI 0.36-0.81) but not in diffuse type subgroup (adjusted HR 0.92, 95% CI 0.58-1.46). High KM grade was an independent prognostic factor for longer 5-year overall survival (adjusted HR 0.59, 95% CI 0.45-0.77) in both intestinal (adjusted HR 0.61, 95% CI 0.44-0.85) and diffuse subgroups (adjusted HR 0.52, 95% CI 0.31-0.86). ICS and KM grade were moderately correlated (ρ = 0.425). When both immune cell score and KM grade were included in the regression analysis, only KM grade remained prognostic.

Conclusions: Both ICS and KM grade are prognostic factors in gastric adenocarcinoma, but immunohistochemistry-based ICS might not have additional prognostic value over hematoxylin-eosin-based KM grade.

Citing Articles

Prediction of Patient Drug Response via 3D Bioprinted Gastric Cancer Model Utilized Patient-Derived Tissue Laden Tissue-Specific Bioink.

Choi Y, Na D, Yoon G, Kim J, Min S, Yi H Adv Sci (Weinh). 2025; 12(10):e2411769.

PMID: 39748450 PMC: 11905052. DOI: 10.1002/advs.202411769.

Multi-Algorithm-Integrated Tertiary Lymphoid Structure Gene Signature for Immune Landscape Characterization and Prognosis in Colorectal Cancer Patients.

Liu X, Li D, Zhang Y, Liu H, Chen P, Zhao Y Biomedicines. 2024; 12(11).

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Distribution and Clinicopathological Features of Mott Cells (Plasma Cells Containing Russell Bodies) in Gastric Cancer: Presence of Mott Cells Is Associated with Favorable Prognosis.

Kobayashi G, Imai T, Sentani K J Clin Med. 2024; 13(3).

PMID: 38337351 PMC: 10856670. DOI: 10.3390/jcm13030658.

The molecular mechanism of actions and clinical utilities of tumor infiltrating lymphocytes in gastrointestinal cancers: a comprehensive review and future prospects toward personalized medicine.

Piroozkhah M, Gholinezhad Y, Piroozkhah M, Shams E, Nazemalhosseini-Mojarad E Front Immunol. 2023; 14:1298891.

PMID: 38077386 PMC: 10704251. DOI: 10.3389/fimmu.2023.1298891.

Gastric Cancer and the Immune System: The Key to Improving Outcomes?.

Keshavjee S, Moy R, Reiner S, Ryeom S, Yoon S Cancers (Basel). 2022; 14(23).

PMID: 36497422 PMC: 9739366. DOI: 10.3390/cancers14235940.

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