Jonathan T Fleming
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Explore the profile of Jonathan T Fleming including associated specialties, affiliations and a list of published articles.
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10
Citations
283
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Recent Articles
1.
Li W, Chen L, Fleming J, Brignola E, Zavalin K, LaGrange A, et al.
J Neurosci
. 2022 May;
42(26):5130-5143.
PMID: 35589396
Cerebellar inhibitory interneurons are important regulators of neural circuit activity for diverse motor and nonmotor functions. The molecular layer interneurons (MLIs), consisting of basket cells (BCs) and stellate cells (SCs),...
2.
Fleming J, Brignola E, Chen L, Guo Y, Zhao S, Wang Q, et al.
Mol Cancer Res
. 2019 Jan;
17(5):1024-1035.
PMID: 30683671
Aberrant activation of the Hedgehog signaling pathway has been linked to the formation of numerous cancer types, including the myogenic soft tissue sarcoma, embryonal rhabdomyosarcoma (eRMS). Here, we report ,...
3.
Cheng F, Fleming J, Chiang C
Dev Biol
. 2018 May;
440(2):152-166.
PMID: 29792854
Neuronal-glial relationships play a critical role in the maintenance of central nervous system architecture and neuronal specification. A deeper understanding of these relationships can elucidate cellular cross-talk capable of sustaining...
4.
Ryan K, Kim P, Fleming J, Brignola E, Cheng F, Litingtung Y, et al.
Dev Biol
. 2017 Oct;
432(1):165-177.
PMID: 28974424
Cerebellar growth and foliation require the Hedgehog-driven proliferation of granule cell precursors (GCPs) in the external granule layer (EGL). However, that increased or extended GCP proliferation generally does not elicit...
5.
Loganathan S, Tang N, Fleming J, Ma Y, Guo Y, Borinstein S, et al.
Oncotarget
. 2016 Jun;
7(28):43504-43517.
PMID: 27259270
Ewing sarcoma is driven by characteristic chromosomal translocations between the EWSR1 gene with genes encoding ETS family transcription factors (EWS-ETS), most commonly FLI1. However, direct pharmacological inhibition of transcription factors...
6.
Williams C, Hempel J, Hao J, Frist A, Williams M, Fleming J, et al.
Cell Rep
. 2015 Mar;
11(1):43-50.
PMID: 25818300
Hedgehog (Hh) signaling plays an integral role in vertebrate development, and its dysregulation has been accepted widely as a driver of numerous malignancies. While a variety of small molecules target...
7.
Fleming J, He W, Hao C, Ketova T, Pan F, Wright C, et al.
Dev Cell
. 2013 Nov;
27(3):278-92.
PMID: 24229643
The prospective white matter (PWM) in the nascent cerebellum contains a transient germinal compartment that produces all postnatally born GABAergic inhibitory interneurons and astrocytes. However, little is known about the...
8.
Benesh A, Fleming J, Chiang C, Carter B, Tyska M
Brain Res
. 2012 Jan;
1440:9-22.
PMID: 22284616
Myosin-1d is a monomeric actin-based motor found in a wide range of tissues, but highly expressed in the nervous system. Previous microarray studies suggest that myosin-1d is found in oligodendrocytes...
9.
Huang X, Liu J, Ketova T, Fleming J, Grover V, Cooper M, et al.
Proc Natl Acad Sci U S A
. 2010 Apr;
107(18):8422-7.
PMID: 20400693
Cerebellar neurons are generated from two germinal neuroepithelia: the ventricular zone (VZ) and rhombic lip. Signaling mechanisms that maintain the proliferative capacity of VZ resident progenitors remain elusive. We reveal...
10.
Huang X, Ketova T, Fleming J, Wang H, Dey S, Litingtung Y, et al.
Development
. 2009 Jul;
136(15):2535-43.
PMID: 19570847
Choroid plexuses (ChPs) are vascularized secretory organs involved in the regulation of brain homeostasis, and function as the blood-cerebrospinal fluid (CSF) barrier. Despite their crucial roles, there is limited understanding...