Jonathan Sulc
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Explore the profile of Jonathan Sulc including associated specialties, affiliations and a list of published articles.
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10
Citations
81
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Recent Articles
1.
Liu Y, Sulc J, Auwerx J
Nat Cell Biol
. 2025 Mar;
27(3):393-407.
PMID: 40065146
Mitochondria are multifaceted organelles with crucial roles in energy generation, cellular signalling and a range of synthesis pathways. The study of mitochondrial biology is complicated by its own small genome,...
2.
Gao A, El Alam G, Zhu Y, Li W, Sulc J, Li X, et al.
Cell Rep
. 2024 Oct;
43(10):114836.
PMID: 39368088
Lifespan is influenced by complex interactions between genetic and environmental factors. Studying those factors in model organisms of a single genetic background limits their translational value for humans. Here, we...
3.
Liu Y, Kimura M, Li X, Sulc J, Wang Q, Rodriguez-Lopez S, et al.
J Hepatol
. 2024 Aug;
82(2):174-188.
PMID: 39181211
Background & Aims: Recent findings reveal the importance of tryptophan-initiated de novo nicotinamide adenine dinucleotide (NAD) synthesis in the liver, a process previously considered secondary to biosynthesis from nicotinamide. The...
4.
Li X, Morel J, Sulc J, De Masi A, Lalou A, Benegiamo G, et al.
Cell Syst
. 2024 Jun;
15(6):497-509.e3.
PMID: 38866010
Susceptibility to metabolic syndrome (MetS) is dependent on genetics, environment, and gene-by-environment interactions, rendering the study of underlying mechanisms challenging. The majority of experiments in model organisms do not incorporate...
5.
Gao A, El Alam G, Zhu Y, Li W, Katsyuba E, Sulc J, et al.
bioRxiv
. 2024 Jan;
PMID: 38293129
Lifespan is influenced by complex interactions between genetic and environmental factors. Studying those factors in model organisms of a single genetic background limits their translational value for humans. Here, we...
6.
Li X, Morel J, Benegiamo G, Poisson J, Bachmann A, Rapin A, et al.
Elife
. 2023 Oct;
12.
PMID: 37855835
Inflammatory gut disorders, including inflammatory bowel disease (IBD), can be impacted by dietary, environmental, and genetic factors. While the incidence of IBD is increasing worldwide, we still lack a complete...
7.
Sulc J, Sjaarda J, Kutalik Z
HGG Adv
. 2022 Jul;
3(3):100124.
PMID: 35832928
Causal inference is a critical step in improving our understanding of biological processes, and Mendelian randomization (MR) has emerged as one of the foremost methods to efficiently interrogate diverse hypotheses...
8.
Sulc J, Sonrel A, Mounier N, Auwerx C, Marouli E, Darrous L, et al.
Commun Biol
. 2021 Sep;
4(1):1064.
PMID: 34518635
Obesity is a major risk factor for a wide range of cardiometabolic diseases, however the impact of specific aspects of body morphology remains poorly understood. We combined the GWAS summary...
9.
Porcu E, Sjaarda J, Lepik K, Carmeli C, Darrous L, Sulc J, et al.
Cold Spring Harb Perspect Med
. 2020 Aug;
11(5).
PMID: 32816877
Major biotechnological advances have facilitated a tremendous boost to the collection of (gen-/transcript-/prote-/methyl-/metabol-)omics data in very large sample sizes worldwide. Coordinated efforts have yielded a deluge of studies associating diseases...
10.
Sulc J, Mounier N, Gunther F, Winkler T, Wood A, Frayling T, et al.
Nat Commun
. 2020 Mar;
11(1):1385.
PMID: 32170055
The growing sample size of genome-wide association studies has facilitated the discovery of gene-environment interactions (GxE). Here we propose a maximum likelihood method to estimate the contribution of GxE to...