Jonathan S Dordick
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Explore the profile of Jonathan S Dordick including associated specialties, affiliations and a list of published articles.
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282
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4404
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Recent Articles
1.
Zhang F, Wang S, Yang J, Fraser K, Gibson J, Wang C, et al.
Carbohydr Polym
. 2025 Jan;
351:123143.
PMID: 39779041
Clostridioides difficile (C. difficile) infection (CDI) is a life-threatening healthcare-associated infection occurring worldwide. C. difficile toxins (toxin A and toxin B) are the major virulence factors, causing CDI-related diarrhea and...
2.
Yang J, Datta P, Xia K, Pomin V, Wang C, Qiao M, et al.
Glycoconj J
. 2024 Dec;
41(6):371-380.
PMID: 39680336
Dengue viruses (DENV) are transmitted to humans through mosquito bites and infect millions globally. DENV uses heparan sulfate (HS) for attachment and cell entry by binding the envelope protein to...
3.
Yang J, Wang W, Huang S, Guo D, Yu L, Qiao W, et al.
Adv Healthc Mater
. 2024 Nov;
14(1):e2402311.
PMID: 39543440
As a promising approach for breast cancer treatment, photothermal therapy (PTT) features high spatial selectivity, noninvasiveness, and minimal drug resistance. IR780 (a near-infrared fluorescent dye) serves as an effective photosensitizer...
4.
Murata H, Kapil K, Kaupbayeva B, Russell A, Dordick J, Matyjaszewski K
Biomacromolecules
. 2024 Oct;
25(11):7433-7445.
PMID: 39422524
This study explores the synthesis and application of artificial zymogens using protein-polymer hybrids to mimic the controlled enzyme activation observed in natural zymogens. Pro-trypsin (pro-TR) and pro-chymotrypsin (pro-CT) hybrids were...
5.
Lin J, Miao J, Schaefer K, Russell C, Pyron R, Zhang F, et al.
Nat Microbiol
. 2024 Sep;
9(10):2553-2569.
PMID: 39285260
Candidalysin, a cytolytic peptide produced by the fungal pathogen Candida albicans, is a key virulence factor. However, its host cell targets remain elusive. Here we performed a genome-wide loss-of-function CRISPR...
6.
Miceli R, Allen N, Subramaniam B, Carmody L, Dordick J, Corr D, et al.
ACS Omega
. 2024 Aug;
9(31):33408-33424.
PMID: 39130564
Piscidin 3 (P3), a peptide produced by fish, and a hexyl ester-modified sophorolipid (SL-HE), have individually shown promise as antimicrobial and anticancer drugs. A recent report by our team revealed...
7.
Qiao M, Wang Z, Zhang J, Li Y, Chen L, Zhang F, et al.
Carbohydr Polym
. 2024 Jun;
341:122297.
PMID: 38876729
The biological activities of heparan sulfate (HS) are intimately related to their molecular weights, degree and pattern of sulfation and homogeneity. The existing methods for synthesizing homogeneous sugar chains of...
8.
A genome-scale screen identifies sulfated glycosaminoglycans as pivotal in epithelial cell damage by
Lin J, Miao J, Schaefer K, Russell C, Pyron R, Zhang F, et al.
bioRxiv
. 2024 Jun;
PMID: 38826446
Candidalysin is a cytolytic peptide produced by the opportunistic fungal pathogen This peptide is a key virulence factor in mouse models of mucosal and hematogenously disseminated candidiasis. Despite intense interest...
9.
Yu Y, Song Y, Zhao Y, Wang N, Wei B, Linhardt R, et al.
Carbohydr Polym
. 2024 Jun;
339:122216.
PMID: 38823901
Low Molecular Weight Heparins (LMWHs) are well-established for use in the prevention and treatment of thrombotic diseases, and as a substitute for unfractionated heparin (UFH) due to their predictable pharmacokinetics...
10.
Yang J, Song Y, Xia K, Pomin V, Wang C, Qiao M, et al.
Mar Drugs
. 2024 May;
22(5).
PMID: 38786623
, a notable pathogen behind respiratory infections, employs specialized proteins to adhere to the respiratory epithelium, an essential process for initiating infection. The role of glycosaminoglycans, especially heparan sulfate, is...