Jonathan R Hart
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Explore the profile of Jonathan R Hart including associated specialties, affiliations and a list of published articles.
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Articles
39
Citations
1375
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Recent Articles
1.
Garcia-Caballero D, Hart J, Vogt P
Pathophysiology
. 2023 Sep;
30(3):389-399.
PMID: 37755396
In this article, we discuss a class of MYC-interacting lncRNAs (long non-coding RNAs) that share the following criteria: They are direct transcriptional targets of MYC. Their expression is coordinated with...
2.
Vogt P, Hart J, Yang S, Zhou Q, Yang D, Wang M
Biochim Biophys Acta Rev Cancer
. 2023 Jul;
1878(5):188947.
PMID: 37394020
Recent cryo-electron microscopic (cryo-EM) investigations have succeeded in the analysis of various structural conformations and functional states of PI3Kα, a dimer consisting of the catalytic subunit p110α and the regulatory...
3.
Garcia-Caballero D, Hart J, Vogt P
Cell Death Dis
. 2023 Feb;
14(2):168.
PMID: 36849510
MYC controls most of the non-coding genome. Several long noncoding transcripts were originally identified in the human B cell line P496-3 and then shown to be required for MYC-driven proliferation...
4.
Liu X, Zhou Q, Hart J, Xu Y, Yang S, Yang D, et al.
Proc Natl Acad Sci U S A
. 2022 Nov;
119(46):e2215621119.
PMID: 36343266
Phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases that perform multiple and important cellular functions. The protein investigated here belongs to class IA of the PI3Ks; it is a...
5.
Hart J, Liu X, Pan C, Liang A, Ueno L, Xu Y, et al.
Proc Natl Acad Sci U S A
. 2022 Sep;
119(38):e2210769119.
PMID: 36095215
Nanobodies and chemical cross-linking were used to gain information on the identity and positions of flexible domains of PI3Kα. The application of chemical cross-linking mass spectrometry (CXMS) facilitated the identification...
6.
Liu X, Yang S, Hart J, Xu Y, Zou X, Zhang H, et al.
Proc Natl Acad Sci U S A
. 2021 Nov;
118(45).
PMID: 34725156
Phosphoinositide 3-kinases (PI3Ks) are lipid kinases essential for growth and metabolism. Their aberrant activation is associated with many types of cancers. Here we used single-particle cryoelectron microscopy (cryo-EM) to determine...
7.
Shirey R, Hart J, Sridharan B, Novick S, Turner L, Zhou B, et al.
Bioorg Med Chem
. 2021 Jun;
42:116246.
PMID: 34130216
We report the discovery of a fluorescent small molecule probe. This probe exhibits an emission increase in the presence of the oncoprotein MYC that can be attenuated by a competing...
8.
Raffeiner P, Hart J, Garcia-Caballero D, Bar-Peled L, Weinberg M, Vogt P
Proc Natl Acad Sci U S A
. 2020 Mar;
117(12):6571-6579.
PMID: 32156728
MYC controls the transcription of large numbers of long noncoding RNAs (lncRNAs). Since MYC is a ubiquitous oncoprotein, some of these lncRNAs probably play a significant role in cancer. We...
9.
Bell C, Raffeiner P, Hart J, Vogt P
Cancers (Basel)
. 2019 Oct;
11(11).
PMID: 31652979
Tumor formation is generally linked to the acquisition of two or more driver genes that cause normal cells to progress from proliferation to abnormal expansion and malignancy. In order to...
10.
Coenen-Stass A, Sork H, Gatto S, Godfrey C, Bhomra A, Krjutskov K, et al.
Mol Ther Nucleic Acids
. 2018 Sep;
13:1-15.
PMID: 30219269
Extracellular small RNAs (sRNAs), including microRNAs (miRNAs), are promising biomarkers for diseases such as Duchenne muscular dystrophy (DMD), although their biological relevance is largely unknown. To investigate the relationship between...