Jonathan P Whiteley
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Explore the profile of Jonathan P Whiteley including associated specialties, affiliations and a list of published articles.
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34
Citations
264
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Recent Articles
11.
Mountain J, Santer P, ONeill D, Smith N, Ciaffoni L, Couper J, et al.
J Appl Physiol (1985)
. 2017 Oct;
124(3):615-631.
PMID: 29074714
Inhomogeneity in the lung impairs gas exchange and can be an early marker of lung disease. We hypothesized that highly precise measurements of gas exchange contain sufficient information to quantify...
12.
Chapman L, Whiteley J, Byrne H, Waters S, Shipley R
J Theor Biol
. 2017 Jan;
418:36-56.
PMID: 28089874
Generating autologous tissue grafts of a clinically useful volume requires efficient and controlled expansion of cell populations harvested from patients. Hollow fibre bioreactors show promise as cell expansion devices, owing...
13.
Optimising cell aggregate expansion in a perfused hollow fibre bioreactor via mathematical modelling
Chapman L, Shipley R, Whiteley J, Ellis M, Byrne H, Waters S
PLoS One
. 2014 Aug;
9(8):e105813.
PMID: 25157635
The need for efficient and controlled expansion of cell populations is paramount in tissue engineering. Hollow fibre bioreactors (HFBs) have the potential to meet this need, but only with improved...
14.
Reinwald Y, Leonard K, Henstock J, Whiteley J, Osborne J, Waters S, et al.
Tissue Eng Part C Methods
. 2014 Jun;
21(1):1-14.
PMID: 24967717
Bioreactors have been widely acknowledged as valuable tools to provide a growth environment for engineering tissues and to investigate the effect of physical forces on cells and cell-scaffold constructs. However,...
15.
Maybank P, Whiteley J
Math Biosci
. 2014 Jan;
248:146-57.
PMID: 24418010
Many mathematical models in biology and physiology are represented by systems of nonlinear differential equations. In recent years these models have become increasingly complex in order to explain the enormous...
16.
Bruce D, Pathmanathan P, Whiteley J
Bull Math Biol
. 2013 Dec;
76(2):431-54.
PMID: 24338526
When modelling tissue-level cardiac electrophysiology, a continuum approximation to the discrete cell-level equations, known as the bidomain equations, is often used to maintain computational tractability. Analysing the derivation of the...
17.
Pathmanathan P, Bernabeu M, Bordas R, Cooper J, Garny A, Pitt-Francis J, et al.
Prog Biophys Mol Biol
. 2010 Jun;
102(2-3):136-55.
PMID: 20553747
Simulation of cardiac electrical activity using the bi-domain equations can be a massively computationally demanding problem. This study provides a comprehensive guide to numerical bi-domain modelling. Each component of bi-domain...
18.
Dunn S, Whiteley J
Ann Biomed Eng
. 2010 Apr;
38(9):2988-99.
PMID: 20387118
A simplified model of periodic breathing, proposed by Whiteley et al. (Math. Med. Biol. 20:205-224, 2003), describes a non-uniform breathing pattern for a lung with an inhomogeneous gas distribution, such...
19.
Whiteley J
Math Biosci
. 2010 Feb;
225(1):44-52.
PMID: 20117117
Mathematical models in biology and physiology are often represented by large systems of non-linear ordinary differential equations. In many cases, an observed behaviour may be written as a linear functional...
20.
Southern J, Plank G, Vigmond E, Whiteley J
IEEE Trans Biomed Eng
. 2009 May;
56(10):2404-12.
PMID: 19457741
The bidomain equations are frequently used to model the propagation of cardiac action potentials across cardiac tissue. At the whole organ level, the size of the computational mesh required makes...