Jonathan P Schuermann
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Explore the profile of Jonathan P Schuermann including associated specialties, affiliations and a list of published articles.
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25
Citations
833
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Recent Articles
1.
Clark N, Katolik A, Welch A, Schorl C, Holloway S, Schuermann J, et al.
Biochemistry
. 2022 Dec;
61(24):2933-2939.
PMID: 36484984
The RNA lariat debranching enzyme is the sole enzyme responsible for hydrolyzing the 2'-5' phosphodiester bond in RNA lariats produced by the spliceosome. Here, we test the ability of Dbr1...
2.
Arrigoni C, Lolicato M, Shaya D, Rohaim A, Findeisen F, Fong L, et al.
Nat Struct Mol Biol
. 2022 Jun;
29(6):537-548.
PMID: 35655098
Every voltage-gated ion channel (VGIC) has a pore domain (PD) made from four subunits, each comprising an antiparallel transmembrane helix pair bridged by a loop. The extent to which PD...
3.
Valentino H, Campbell A, Schuermann J, Sultana N, Nam H, Leblanc S, et al.
J Biol Chem
. 2020 Jun;
295(32):11042-11055.
PMID: 32527723
Allicin is a component of the characteristic smell and flavor of garlic (). A flavin-containing monooxygenase (FMO) produced by (AsFMO) was previously proposed to oxidize -allyl-l-cysteine (SAC) to alliin, an...
4.
Clark N, Katolik A, Roberts K, Taylor A, Holloway S, Schuermann J, et al.
Proc Natl Acad Sci U S A
. 2016 Dec;
113(51):14727-14732.
PMID: 27930312
Intron lariats are circular, branched RNAs (bRNAs) produced during pre-mRNA splicing. Their unusual chemical and topological properties arise from branch-point nucleotides harboring vicinal 2',5'- and 3',5'-phosphodiester linkages. The 2',5'-bonds must...
5.
Lye M, Sharma M, El Omari K, Filman D, Schuermann J, Hogle J, et al.
EMBO J
. 2015 Oct;
34(23):2937-52.
PMID: 26511021
Herpesvirus nucleocapsids escape from the nucleus in a process orchestrated by a highly conserved, viral nuclear egress complex. In human cytomegalovirus, the complex consists of two proteins, UL50 and UL53....
6.
Montemayor E, Katolik A, Clark N, Taylor A, Schuermann J, Combs D, et al.
Nucleic Acids Res
. 2014 Aug;
42(16):10845-55.
PMID: 25123664
The enzymatic processing of cellular RNA molecules requires selective recognition of unique chemical and topological features. The unusual 2',5'-phosphodiester linkages in RNA lariats produced by the spliceosome must be hydrolyzed...
7.
Poor C, Wegner S, Li H, Dlouhy A, Schuermann J, Sanishvili R, et al.
Proc Natl Acad Sci U S A
. 2014 Mar;
111(11):4043-8.
PMID: 24591629
The paralogous iron-responsive transcription factors Aft1 and Aft2 (activators of ferrous transport) regulate iron homeostasis in Saccharomyces cerevisiae by activating expression of iron-uptake and -transport genes when intracellular iron is...
8.
Duda D, Olszewski J, Schuermann J, Kurinov I, Miller D, Nourse A, et al.
Structure
. 2013 May;
21(6):1030-41.
PMID: 23707686
A distinct mechanism for ubiquitin (Ub) ligation has recently been proposed for the RING1-IBR-RING2 (RBR) family of E3s: an N-terminal RING1 domain recruits a thioester-linked intermediate complex between Ub and...
9.
Galaleldeen A, Taylor A, Chen D, Schuermann J, Holloway S, Hou S, et al.
J Biol Chem
. 2013 May;
288(30):22068-79.
PMID: 23703617
Chlamydia trachomatis infection is the most common sexually transmitted bacterial disease. Left untreated, it can lead to ectopic pregnancy, pelvic inflammatory disease, and infertility. Here we present the structure of...
10.
Singh H, Schuermann J, Reilly T, Calcutt M, Tanner J
J Mol Biol
. 2010 Oct;
404(4):639-49.
PMID: 20934434
The e (P4) phosphatase from Haemophilus influenzae functions in a vestigial NAD(+) utilization pathway by dephosphorylating nicotinamide mononucleotide to nicotinamide riboside. P4 is also the prototype of class C acid...