Jonathan Moggs
Overview
Explore the profile of Jonathan Moggs including associated specialties, affiliations and a list of published articles.
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26
Citations
531
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Recent Articles
11.
McMahon M, Ding S, Jimenez L, Terranova R, Gerard M, Vitobello A, et al.
Mol Pharmacol
. 2018 Oct;
95(1):97-105.
PMID: 30361333
The constitutive androstane receptor (CAR) is a xenobiotic sensor expressed in hepatocytes that activates genes involved in drug metabolism, lipid homeostasis, and cell proliferation. Much progress has been made in...
12.
Moggs J, Terranova R
Toxicol Res (Camb)
. 2018 Aug;
7(4):606-617.
PMID: 30090610
Pleiotropic xenobiotics can trigger dynamic alterations in mammalian chromatin structure and function but many of these are likely non-adverse and simply reflect short-term changes in DNA transactions underlying normal homeostatic,...
13.
Felter S, Foreman J, Boobis A, Corton J, Doi A, Flowers L, et al.
Regul Toxicol Pharmacol
. 2017 Nov;
92:1-7.
PMID: 29113941
The Toxicology Forum sponsored a workshop in October 2016, on the human relevance of rodent liver tumors occurring via nongenotoxic modes of action (MOAs). The workshop focused on two nuclear...
14.
Bhoumik P, Del Rio-Espinola A, Hahne F, Moggs J, Grenet O
Toxicol Pathol
. 2016 Dec;
45(1):119-126.
PMID: 27932582
The emerging field of translational safety genetics is providing new opportunities to enhance drug discovery and development. Genetic variation in therapeutic drug targets, off-target interactors and relevant drug metabolism/disposition pathways...
15.
Brasa S, Mueller A, Jacquemont S, Hahne F, Rozenberg I, Peters T, et al.
Clin Epigenetics
. 2016 Feb;
8:15.
PMID: 26855684
Background: Fragile X syndrome (FXS) is the most common form of inherited intellectual disability, resulting from the loss of function of the fragile X mental retardation 1 (FMR1) gene. The...
16.
Chapman V, Zollinger T, Terranova R, Moggs J, Kimber I, Dearman R
Toxicol Sci
. 2014 Mar;
139(2):350-61.
PMID: 24675093
Epigenetic regulation of gene expression plays a pivotal role in the orchestration of immune responses and may determine the vigor, quality, or longevity of such responses. Chemical allergens can be...
17.
Unterberger E, Eichner J, Wrzodek C, Lempiainen H, Luisier R, Terranova R, et al.
Int J Cancer
. 2014 Feb;
135(7):1574-85.
PMID: 24535843
The process of hepatocarcinogenesis in the diethylnitrosamine (DEN) initiation/phenobarbital (PB) promotion mouse model involves the selective clonal outgrowth of cells harboring oncogene mutations in Ctnnb1, while spontaneous or DEN-only-induced tumors...
18.
Luisier R, Unterberger E, Goodman J, Schwarz M, Moggs J, Terranova R, et al.
Nucleic Acids Res
. 2014 Jan;
42(7):4180-95.
PMID: 24464994
Gene regulatory interactions underlying the early stages of non-genotoxic carcinogenesis are poorly understood. Here, we have identified key candidate regulators of phenobarbital (PB)-mediated mouse liver tumorigenesis, a well-characterized model of...
19.
Kronenberg S, Baumann A, de Haan L, Hinton H, Moggs J, Theil F, et al.
Drug Discov Today
. 2013 Aug;
18(23-24):1138-43.
PMID: 23942260
Nonclinical safety testing of new biotherapeutic entities represents its own challenges and opportunities in drug development. Hot topics in this field have been discussed recently at the 2nd Annual BioSafe...
20.
Sathish J, Sethu S, Bielsky M, de Haan L, French N, Govindappa K, et al.
Nat Rev Drug Discov
. 2013 Mar;
12(4):306-24.
PMID: 23535934
Immunomodulatory biologics, which render their therapeutic effects by modulating or harnessing immune responses, have proven their therapeutic utility in several complex conditions including cancer and autoimmune diseases. However, unwanted adverse...