Jonathan Melamed
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Explore the profile of Jonathan Melamed including associated specialties, affiliations and a list of published articles.
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199
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5812
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Recent Articles
1.
Zhang X, Lan R, Liu Y, Pillarisetty V, Li D, Zhao C, et al.
NPJ Precis Oncol
. 2025 Mar;
9(1):58.
PMID: 40032924
Neoadjuvant therapy (NAT) is increasingly being used for pancreatic ductal adenocarcinoma (PDAC). This study investigates how NAT differentially impacts PDAC's carcinoma cells and the tumor microenvironment (TME). Spatial transcriptomics was...
2.
Mannas M, Deng F, Ion-Margineanu A, Freudiger C, Lough L, Huang W, et al.
J Urol
. 2024 Dec;
101097JU0000000000004393.
PMID: 39689226
Purpose: Balancing surgical margins and functional outcomes is crucial during radical prostatectomy for prostate cancer. Stimulated Raman histology (SRH) is a novel, real-time imaging technique that provides histologic images of...
3.
Mannas M, Deng F, Ion-Margineanu A, Freudiger C, Jones D, Hoskoppal D, et al.
Urol Oncol
. 2024 Aug;
43(1):64.e19-64.e25.
PMID: 39129081
Background: In-field or in-margin recurrence after partial gland cryosurgical ablation (PGCA) of prostate cancer (PCa) remains a limitation of the paradigm. Stimulated Raman histology (SRH) is a novel microscopic technique...
4.
Zhang X, Lan R, Liu Y, Pillarisetty V, Li D, Zhao C, et al.
Res Sq
. 2024 May;
PMID: 38798691
Background: Neoadjuvant therapy (NAT) is increasingly being used for pancreatic ductal adenocarcinoma (PDAC) treatment. However, its specific effects on carcinoma cells and the tumor microenvironment (TME) are not fully understood....
5.
Sobel A, Melamed J, Haas D, LeBlanc G, Cirone A, Constantinides M
bioRxiv
. 2024 May;
PMID: 38798453
Mucosal-associated invariant T (MAIT) cells are predominantly located in barrier tissues where they rapidly respond to pathogens and commensals by recognizing microbial derivatives of riboflavin synthesis. Early-life exposure to these...
6.
Wise D, Pachynski R, Denmeade S, Aggarwal R, Deng J, Febles V, et al.
Prostate Cancer Prostatic Dis
. 2024 Feb;
PMID: 38341461
Background: Dickkopf-related protein 1 (DKK1) is a Wingless-related integrate site (Wnt) signaling modulator that is upregulated in prostate cancers (PCa) with low androgen receptor expression. DKN-01, an IgG4 that neutralizes...
7.
Pu T, Wang J, Wei J, Zeng A, Zhang J, Chen J, et al.
Sci Adv
. 2024 Feb;
10(6):eadi4935.
PMID: 38335292
Prostate cancer (PC) develops in a microenvironment where the stromal cells modulate adjacent tumor growth and progression. Here, we demonstrated elevated levels of monoamine oxidase B (MAOB), a mitochondrial enzyme...
8.
Troxel A, Bind M, Flotte T, Cordon-Cardo C, Decker L, Finn A, et al.
PLoS One
. 2024 Jan;
19(1):e0285645.
PMID: 38198481
Importance: SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or organ dysfunction after the acute phase of infection, termed Post-Acute Sequelae of SARS-CoV-2 (PASC), or long COVID. The...
9.
Aleksandrovych M, Strassberg M, Melamed J, Xu M
Biomed Opt Express
. 2023 Nov;
14(11):5833-5850.
PMID: 38021115
We present single-shot high-performance quantitative phase imaging with a physics-inspired plug-and-play denoiser for polarization differential interference contrast (PDIC) microscopy. The quantitative phase is recovered by the alternating direction method of...
10.
Pusic M, Rapkiewicz A, Raykov T, Melamed J
Med Decis Making
. 2023 Jul;
43(6):680-691.
PMID: 37401184
Background: For the representative problem of prostate cancer grading, we sought to simultaneously model both the continuous nature of the case spectrum and the decision thresholds of individual pathologists, allowing...