Jonathan M Boulter
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Explore the profile of Jonathan M Boulter including associated specialties, affiliations and a list of published articles.
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21
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1113
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Recent Articles
1.
Cole D, Sami M, Scott D, Rizkallah P, Borbulevych O, Todorov P, et al.
Front Immunol
. 2013 Jun;
4:168.
PMID: 23805144
Natural T cell receptors (TCRs) generally bind to their cognate pMHC molecules with weak affinity and fast kinetics, limiting their use as therapeutic agents. Using phage display, we have engineered...
2.
Liddy N, Molloy P, Bennett A, Boulter J, Jakobsen B, Li Y
Mol Biotechnol
. 2010 Feb;
45(2):140-9.
PMID: 20143183
Previously, we have described the use of phage display to generate high affinity disulfide bond-linked T cell receptors (TCRs). The affinities of the mutant TCRs were analysed after refolding of...
3.
Cole D, Dunn S, Sami M, Boulter J, Jakobsen B, Sewell A
Mol Immunol
. 2008 Feb;
45(9):2700-9.
PMID: 18243322
Activation of cytotoxic T cells is initiated by engagement of the T-cell receptor (TCR) with peptide-major histocompatibility class I complexes (pMHCI). The CD8 co-receptor also binds to pMHCI, but at...
4.
Sami M, Rizkallah P, Dunn S, Molloy P, Moysey R, Vuidepot A, et al.
Protein Eng Des Sel
. 2007 Jul;
20(8):397-403.
PMID: 17644531
Naturally selected T-cell receptors (TCRs) are characterised by low binding affinities, typically in the range 1-100 microM. Crystal structures of syngeneic TCRs bound to peptide major histocompatibility complex (pMHC) antigens...
5.
Cole D, Pumphrey N, Boulter J, Sami M, Bell J, Gostick E, et al.
J Immunol
. 2007 Apr;
178(9):5727-34.
PMID: 17442956
T cell recognition is initiated by the binding of TCRs to peptide-MHCs (pMHCs), the interaction being characterized by weak affinity and fast kinetics. Previously, only 16 natural TCR/pMHC interactions have...
6.
Wooldridge L, Lissina A, Vernazza J, Gostick E, Laugel B, Hutchinson S, et al.
Eur J Immunol
. 2007 Apr;
37(5):1323-33.
PMID: 17429845
CD8(+) cytotoxic T lymphocytes (CTL) are key determinants of immunity to intracellular pathogens and neoplastic cells. Recognition of specific antigens in the form of peptide-MHC class I complexes (pMHCI) presented...
7.
Boulter J, Schmitz N, Sewell A, Godkin A, Bachmann M, Gallimore A
Eur J Immunol
. 2007 Feb;
37(3):798-806.
PMID: 17295390
The interaction between T cell receptors (TCR) and peptide-major histocompatibility complex (pMHC) antigens can lead to varying degrees of agonism (T cell activation), or antagonism. The P14 TCR recognises the...
8.
Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor
Gostick E, Cole D, Hutchinson S, Wooldridge L, Tafuro S, Laugel B, et al.
Eur J Immunol
. 2007 Feb;
37(2):479-86.
PMID: 17273992
HLA-A*6801 exhibits several unusual features. First, it is known to bind weakly to CD8 due to the presence of an A245V substitution in the alpha3 domain. Second, it is able...
9.
Cole D, Rizkallah P, Boulter J, Sami M, Vuidepot A, Glick M, et al.
Proteins
. 2007 Jan;
67(1):65-74.
PMID: 17243170
Human CD8 is a T cell coreceptor, which binds to pHLA I and plays a pivotal role in the activation of cytotoxic T lymphocytes. Soluble recombinant CD8 alphaalpha has been...
10.
Cole D, Rizkallah P, Sami M, Lissin N, Gao F, Bell J, et al.
Acta Crystallogr Sect F Struct Biol Cryst Commun
. 2006 Mar;
61(Pt 3):285-7.
PMID: 16511019
The class I CD8 positive T-cell response is involved in a number of conditions in which artificial down-regulation and control would be therapeutically beneficial. Such conditions include a number of...