Jonathan K Alder
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Explore the profile of Jonathan K Alder including associated specialties, affiliations and a list of published articles.
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52
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2710
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Recent Articles
1.
Sanford S, Badstubner M, Gerber M, Mannherz W, Lampl N, Dannenberg R, et al.
bioRxiv
. 2025 Feb;
PMID: 39975053
Most cancers upregulate the telomere lengthening enzyme telomerase to achieve unlimited cell division. How chemotherapeutic nucleoside 6-thio-2'-deoxyguanosine (6-thio-dG) targets telomerase to inhibit telomere maintenance in cancer cells and tumors was...
2.
Das A, Wang X, Devonshire K, Lyons E, Popescu I, Zhou Z, et al.
J Immunol
. 2024 Jul;
213(6):898-905.
PMID: 39072690
Lung transplant remains the primary therapeutic option for patients with end-stage lung disease, but long-term survival rates remain suboptimal compared with other solid organ transplants. Acute cellular rejection (ACR) is...
3.
Hinchie A, Sanford S, Loughridge K, Sutton R, Parikh A, Gil Silva A, et al.
Nat Commun
. 2024 Jun;
15(1):4681.
PMID: 38824190
The telomere sequence, TTAGGG, is conserved across all vertebrates and plays an essential role in suppressing the DNA damage response by binding a set of proteins termed shelterin. Changes in...
4.
Karimian K, Groot A, Huso V, Kahidi R, Tan K, Sholes S, et al.
Science
. 2024 Apr;
384(6695):533-539.
PMID: 38603523
Short telomeres cause age-related disease, and long telomeres contribute to cancer; however, the mechanisms regulating telomere length are unclear. We developed a nanopore-based method, which we call Telomere Profiling, to...
5.
Shah F, Bahudhanapati H, Jiang M, Tabary M, van der Geest R, Tolman N, et al.
Am J Respir Cell Mol Biol
. 2024 Feb;
70(5):379-391.
PMID: 38301257
GDF15 (growth differentiation factor 15) is a stress cytokine with several proposed roles, including support of stress erythropoiesis. Higher circulating GDF15 levels are prognostic of mortality during acute respiratory distress...
6.
Karimian K, Groot A, Huso V, Kahidi R, Tan K, Sholes S, et al.
bioRxiv
. 2024 Jan;
PMID: 38187739
Short telomeres cause age-related disease and long telomeres predispose to cancer; however, the mechanisms regulating telomere length are unclear. To probe these mechanisms, we developed a nanopore sequencing method, Telomere...
7.
Huckestein B, Zeng K, Westcott R, Alder J, Antos D, Kolls J, et al.
Am J Pathol
. 2023 Dec;
194(3):384-401.
PMID: 38159723
Respiratory tract virus infections cause millions of hospitalizations worldwide each year. Severe infections lead to lung damage that coincides with persistent inflammation and a lengthy repair period. Vaccination and antiviral...
8.
Bahudhanapati H, Tan J, Apel R, Seeliger B, Schupp J, Li X, et al.
Eur Respir J
. 2023 Nov;
63(1).
PMID: 37918852
Rationale: Recent data suggest that the localisation of airway epithelial cells in the distal lung in idiopathic pulmonary fibrosis (IPF) may drive pathology. We set out to discover whether chemokines...
9.
van der Geest R, Penaloza H, Xiong Z, Gonzalez-Ferrer S, An X, Li H, et al.
Am J Physiol Lung Cell Mol Physiol
. 2023 Sep;
325(5):L604-L616.
PMID: 37724373
Basic leucine zipper transcription factor ATF-like 2 (BATF2) is a transcription factor that is emerging as an important regulator of the innate immune system. BATF2 is among the top upregulated...
10.
Sullivan D, Bello F, Silva A, Redding K, Giordano L, Hinchie A, et al.
Aging Cell
. 2023 Sep;
22(10):e13941.
PMID: 37688329
Mitochondria play essential roles in metabolic support and signaling within all cells. Congenital and acquired defects in mitochondria are responsible for several pathologies, including premature entrance to cellar senescence. Conversely,...