Jonathan H Esensten
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Explore the profile of Jonathan H Esensten including associated specialties, affiliations and a list of published articles.
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Articles
24
Citations
2003
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Recent Articles
1.
Melocchi A, Schmittlein B, Sadhu S, Nayak S, Lares A, Uboldi M, et al.
J Control Release
. 2025 Feb;
381:113561.
PMID: 39993639
Advanced therapy medicinal products (ATMPs), particularly genetically engineered cell-based therapies, are a major class of drugs with several high-profile Food and Drug Administration (FDA) approvals in the past decade. However,...
2.
Kliegman M, Zaghlula M, Abrahamson S, Esensten J, Wilson R, Urnov F, et al.
Nature
. 2024 Jul;
634(8033):307-314.
PMID: 39019069
Twenty genetic therapies have been approved by the US Food and Drug Administration to date, a number that now includes the first CRISPR genome-editing therapy for sickle cell disease-CASGEVY (exagamglogene...
3.
Melocchi A, Schmittlein B, Jones A, Ainane Y, Rizvi A, Chan D, et al.
Cytotherapy
. 2024 Apr;
26(9):1095-1104.
PMID: 38647505
Background Aims: The production of commercial autologous cell therapies such as chimeric antigen receptor T cells requires complex manual manufacturing processes. Skilled labor costs and challenges in manufacturing scale-out have...
4.
Tang Q, Leung J, Peng Y, Sanchez-Fueyo A, Lozano J, Lam A, et al.
Sci Transl Med
. 2022 Nov;
14(669):eabo2628.
PMID: 36322627
Promoting immune tolerance to transplanted organs can minimize the amount of immunosuppressive drugs that patients need to take, reducing lifetime risks of mortality and morbidity. Regulatory T cells (T) are...
5.
Shy B, Vykunta V, Ha A, Talbot A, Roth T, Nguyen D, et al.
Nat Biotechnol
. 2022 Aug;
41(4):521-531.
PMID: 36008610
Enhancing CRISPR-mediated site-specific transgene insertion efficiency by homology-directed repair (HDR) using high concentrations of double-stranded DNA (dsDNA) with Cas9 target sequences (CTSs) can be toxic to primary cells. Here, we...
6.
Balcerek J, Shy B, Putnam A, Masiello L, Lares A, Dekovic F, et al.
Front Immunol
. 2021 Dec;
12:744763.
PMID: 34867967
We report on manufacturing outcomes for 41 autologous polyclonal regulatory T cell (PolyTreg) products for 7 different Phase 1 clinical trials over a 10-year period (2011-2020). Data on patient characteristics,...
7.
Bainbridge E, Hsue P, Esensten J, Lynch K, Hendrickson C, Doernberg S, et al.
Open Forum Infect Dis
. 2021 Aug;
8(8):ofab385.
PMID: 34405093
We characterized the antibody composition of coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) and the immunologic responses of hospitalized COVID-19 patients after receiving CCP or nonimmune fresh frozen plasma. Despite...
8.
Dong S, Hiam-Galvez K, Mowery C, Herold K, Gitelman S, Esensten J, et al.
JCI Insight
. 2021 Jul;
6(18).
PMID: 34324441
BACKGROUNDA previous phase I study showed that the infusion of autologous Tregs expanded ex vivo into patients with recent-onset type 1 diabetes (T1D) had an excellent safety profile. However, the...
9.
Matthay Z, Hellmann Z, Callcut R, Matthay E, Nunez-Garcia B, Duong W, et al.
J Trauma Acute Care Surg
. 2021 Jun;
91(1):24-33.
PMID: 34144557
Background: Despite the widespread institution of modern massive transfusion protocols with balanced blood product ratios, survival for patients with traumatic hemorrhage receiving ultramassive transfusion (UMT) (defined as ≥20 U of...
10.
Lynch K, Whitman J, Lacanienta N, Beckerdite E, Kastner S, Shy B, et al.
Clin Infect Dis
. 2021 Jan;
72(2):301-308.
PMID: 33501951
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can be detected indirectly by measuring the host immune response. For some viruses, antibody concentrations correlate with host protection and viral...