Jonathan C Swaffield
Overview
Explore the profile of Jonathan C Swaffield including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
25
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Recent Articles
1.
Appiah K, Blat Y, Robertson B, Pearce B, Pedicord D, Gentles R, et al.
J Biomol Screen
. 2013 Nov;
19(4):595-605.
PMID: 24241710
Recent genetic evidence suggests that the diacylglycerol lipase (DAGL-α) isoform is the major biosynthetic enzyme for the most abundant endocannabinoid, 2-arachidonoyl-glycerol (2-AG), in the central nervous system. Revelation of its...
2.
Yu X, Miranda M, Liu Z, Patel S, Nguyen N, Carson K, et al.
J Biomol Screen
. 2009 Dec;
15(1):72-9.
PMID: 19959816
Deoxycytidine kinase (dCK) phosphorylates deoxycytidine, deoxyguanosine, and deoxyadenosine and plays an important role in the salvage pathway of nucleoside metabolism. dCK is also required for the phosphorylation of several antiviral...
3.
Jessop T, Tarver J, Carlsen M, Xu A, Healy J, Heim-Riether A, et al.
Bioorg Med Chem Lett
. 2009 Oct;
19(23):6784-7.
PMID: 19836232
A series of deoxycytidine kinase inhibitors was simultaneously optimized for potency and PK properties. A co-crystal structure then allowed merging this series with a high throughput screening hit to afford...
4.
Tarver J, Jessop T, Carlsen M, Augeri D, Fu Q, Healy J, et al.
Bioorg Med Chem Lett
. 2009 Oct;
19(23):6780-3.
PMID: 19836229
A series of potent piperidine-linked cytosine derivatives were prepared as inhibitors of deoxycytidine kinase (dCK). Compound 9h was discovered to be a potent inhibitor of dCK and shows a good...
5.
Liu X, Kramer J, Swaffield J, Hu Y, Chai G, Wilson A
Mutat Res
. 2008 May;
653(1-2):63-9.
PMID: 18485802
The potential genotoxicity of drug candidates is a serious concern during drug development. Therefore, it is important to assess the potential genotoxicity and mutagenicity of a compound early in the...