Jonathan C P Roos
Overview
Explore the profile of Jonathan C P Roos including associated specialties, affiliations and a list of published articles.
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Articles
37
Citations
290
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Recent Articles
1.
Sullivan A, Murthy R, Roos J
Eye (Lond)
. 2023 Sep;
38(4):817.
PMID: 37777660
No abstract available.
2.
Boer D, Mirzaian M, Ferraz M, Zwiers K, Baks M, Hazeu M, et al.
J Lipid Res
. 2020 Dec;
62:100018.
PMID: 33361282
Deficiency of glucocerebrosidase (GBA), a lysosomal β-glucosidase, causes Gaucher disease. The enzyme hydrolyzes β-glucosidic substrates and transglucosylates cholesterol to cholesterol-β-glucoside. Here we show that recombinant human GBA also cleaves β-xylosides...
3.
Roos J, Eglitis V, Murthy R
Ophthalmic Plast Reconstr Surg
. 2020 Nov;
37(4):366-371.
PMID: 33237667
Background: Thyroid eye disease (TED) is characterized by orbital inflammation and complicated by extraocular muscle fibrosis. Treatment with rapamycin/sirolimus has been reported to improve ocular motility and disease manifestations in...
4.
Roos J, Hyry H, Murthy R
N Engl J Med
. 2020 May;
382(20):1959.
PMID: 32402171
No abstract available.
5.
Roos J, Murthy R
Curr Opin Ophthalmol
. 2019 Jul;
30(5):401-406.
PMID: 31313753
Purpose Of Review: To offer an update on advances and controversies in the assessment, investigation and treatment of thyroid eye disease (TED), a disfiguring orbital autoimmune disease, which can manifest...
6.
Murthy R, Roos J, Goldberg R
Curr Opin Ophthalmol
. 2019 Jul;
30(5):395-400.
PMID: 31261189
Purpose Of Review: The use of dermal filler in the periocular area is increasing - both for functional and aesthetic indications. Hyaluronic acid fillers dominate the market; these treatments offer...
7.
Roos J, Murthy R
Eye (Lond)
. 2019 Feb;
33(4):679-682.
PMID: 30755726
Background: Rapamycin (alternatively known as sirolimus) is a macrolide immunosuppressant commonly used for organ transplantation. It acts both on lymphocytes through the mechanistic target of rapamycin (mTOR) pathway to reduce...
8.
Winter A, Salimi A, Ospina L, Roos J
Br J Ophthalmol
. 2019 Jan;
103(3):315-326.
PMID: 30612093
Gaucher disease (GD) results from a deficiency of glucocerebrosidase activity and the subsequent accumulation of the enzyme's metabolites, principally glucosylsphingosine and glucosylceramide. There are three principal forms: Type I, which...
9.
10.
Das T, Roos J, Patterson A, Graves M, Murthy R
Eye (Lond)
. 2018 Dec;
33(2):235-243.
PMID: 30538310
Imaging in thyroid eye disease (TED) is used to exclude other diagnoses, assess for apical crowding and plan surgery. But to quantify TED activity objectively, subjective clinical scoring assessments remain...