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Jonathan A Stiber

Explore the profile of Jonathan A Stiber including associated specialties, affiliations and a list of published articles. Areas
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Articles 26
Citations 515
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Recent Articles
1.
McGowan S, Gilfanov N, Chandurkar M, Stiber J, Han S
Am J Respir Cell Mol Biol . 2024 Jan; 70(4):308-321. PMID: 38271699
Alveolar septation increases gas-exchange surface area and requires coordinated cytoskeletal rearrangement in lung fibroblasts (LFs) to balance the demands of contraction and cell migration. We hypothesized that DBN (drebrin), a...
2.
Zhang L, Wu J, Jean-Charles P, Murali P, Zhang W, Jazic A, et al.
J Biol Chem . 2023 Jun; 299(7):104911. PMID: 37311534
Reversible lysine-63 (K63) polyubiquitination regulates proinflammatory signaling in vascular smooth muscle cells (SMCs) and plays an integral role in atherosclerosis. Ubiquitin-specific peptidase 20 (USP20) reduces NFκB activation triggered by proinflammatory...
3.
Zhang H, Graham V, Nepliouev I, Stiber J, Rosenberg P
bioRxiv . 2023 May; PMID: 37205552
Cardiomyocytes in the sinoatrial node (SAN) are specialized to undergo spontaneous diastolic depolarization (DD) to create action potentials (AP) that serve as the origin of the heartbeat. Two cellular clocks...
4.
Wu J, Zhang L, Nepliouev I, Brian L, Huang T, Snow K, et al.
Cardiovasc Res . 2021 Apr; 118(3):772-784. PMID: 33914863
Aims: The F-actin-binding protein Drebrin inhibits smooth muscle cell (SMC) migration, proliferation, and pro-inflammatory signalling. Therefore, we tested the hypothesis that Drebrin constrains atherosclerosis. Methods And Results: SM22-Cre+/Dbnflox/flox/Ldlr-/- (SMC-Dbn-/-/Ldlr-/-) and...
5.
Karnam S, Maddala R, Stiber J, Rao P
Dev Dyn . 2021 Apr; 250(11):1600-1617. PMID: 33896079
Background: Lens morphogenesis, architecture, and clarity are known to be critically dependent on actin cytoskeleton organization and cell adhesive interactions. There is limited knowledge, however regarding the identity and role...
6.
Urak K, Blanco G, Shubham S, Lin L, Dassie J, Thiel W, et al.
Nat Commun . 2019 Jan; 10(1):116. PMID: 30631065
The development of multiple organ dysfunction syndrome (MODS) following infection or tissue injury is associated with increased patient morbidity and mortality. Extensive cellular injury results in the release of nuclear...
7.
Jean-Charles P, Wu J, Zhang L, Kaur S, Nepliouev I, Stiber J, et al.
Arterioscler Thromb Vasc Biol . 2018 Oct; 38(10):2295-2305. PMID: 30354204
Objective- Signaling that activates NFκB (nuclear factor κB) in smooth muscle cells (SMCs) is integral to atherosclerosis and involves reversible ubiquitination that activates proteins downstream of proatherogenic receptors. Deubiquitination of...
8.
Mourad A, Stiber J, Perfect J, Johnson M
J Antimicrob Chemother . 2018 Oct; 74(1):228-233. PMID: 30295798
Objectives: Voriconazole, a triazole antifungal, is frequently prescribed in a complex patient population with comorbidities that require concomitant administration of QT interval-prolonging medications. We sought to evaluate QT interval prolongation...
9.
Zhang L, Wu J, Huang T, Nepliouev I, Brian L, Zhang Z, et al.
Cardiovasc Res . 2018 Jun; 114(13):1806-1815. PMID: 29931051
Aims: The actin-binding protein Drebrin is up-regulated in response to arterial injury and reduces smooth muscle cell (SMC) migration and proliferation through its interaction with the actin cytoskeleton. We, therefore,...
10.
Jean-Charles P, Yu S, Abraham D, Kommaddi R, Mao L, Strachan R, et al.
JCI Insight . 2017 Sep; 2(17). PMID: 28878120
The oncoprotein Mdm2 is a RING domain-containing E3 ubiquitin ligase that ubiquitinates G protein-coupled receptor kinase 2 (GRK2) and β-arrestin2, thereby regulating β-adrenergic receptor (βAR) signaling and endocytosis. Previous studies...