Jon H Olafsson
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Explore the profile of Jon H Olafsson including associated specialties, affiliations and a list of published articles.
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1941
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Recent Articles
1.
Ivarsdottir E, Gudmundsson J, Tragante V, Sveinbjornsson G, Kristmundsdottir S, Stacey S, et al.
Nat Genet
. 2024 Oct;
56(11):2422-2433.
PMID: 39472694
Discovery of cancer risk variants in the sequence of the germline genome can shed light on carcinogenesis. Here we describe gene burden association analyses, aggregating rare missense and loss of...
2.
Olafsdottir T, Stacey S, Sveinbjornsson G, Thorleifsson G, Norland K, Sigurgeirsson B, et al.
Cancer Res
. 2021 Feb;
81(8):1954-1964.
PMID: 33602785
The success of genome-wide association studies (GWAS) in identifying common, low-penetrance variant-cancer associations for the past decade is undisputed. However, discovering additional high-penetrance cancer mutations in unknown cancer predisposing genes...
3.
Sarin K, Lin Y, Daneshjou R, Ziyatdinov A, Thorleifsson G, Rubin A, et al.
Nat Commun
. 2020 Feb;
11(1):820.
PMID: 32041948
Cutaneous squamous cell carcinoma (SCC) is one of the most common cancers in the United States. Previous genome-wide association studies (GWAS) have identified 14 single nucleotide polymorphisms (SNPs) associated with...
4.
Rafnar T, Sigurjonsdottir G, Stacey S, Halldorsson G, Sulem P, Pardo L, et al.
J Natl Cancer Inst
. 2018 May;
110(9):967-974.
PMID: 29767749
Background: Most pathogenic mutations in the BRCA2 gene carry a high risk of hereditary breast and ovarian cancer (HBOC). However, a stop-gain mutation, K3326* (rs11571833), confers risk of lung cancer...
5.
Thorleifsdottir R, Sigurdardottir S, Sigurgeirsson B, Olafsson J, Petersen H, Sigurdsson M, et al.
J Am Acad Dermatol
. 2016 Aug;
75(5):889-896.
PMID: 27520394
Background: Carriage of the HLA-Cw*0602 allele is associated with a particular set of clinical features and treatment responses in psoriasis. Tonsillectomy can improve psoriasis. Objectives: We sought to evaluate whether...
6.
Thorleifsdottir R, Eysteinsdottir J, Olafsson J, Sigurdsson M, Johnston A, Valdimarsson H, et al.
Acta Derm Venereol
. 2016 Mar;
96(6):788-91.
PMID: 26984718
Streptococcal throat infections are known to trigger or exacerbate psoriasis, and several studies support the benefit of tonsillectomy. To evaluate the potential of tonsillectomy as a treatment, we used a...
7.
Stacey S, Helgason H, Gudjonsson S, Thorleifsson G, Zink F, Sigurdsson A, et al.
Nat Commun
. 2015 Apr;
6:6825.
PMID: 25855136
In an ongoing screen for DNA sequence variants that confer risk of cutaneous basal cell carcinoma (BCC), we conduct a genome-wide association study (GWAS) of 24,988,228 SNPs and small indels...
8.
Stacey S, Sulem P, Gudbjartsson D, Jonasdottir A, Thorleifsson G, Gudjonsson S, et al.
Hum Mol Genet
. 2014 Jan;
23(11):3045-53.
PMID: 24403052
To search for new sequence variants that confer risk of cutaneous basal cell carcinoma (BCC), we conducted a genome-wide association study of 38.5 million single nucleotide polymorphisms (SNPs) and small...
9.
Iles M, Law M, Stacey S, Han J, Fang S, Pfeiffer R, et al.
Nat Genet
. 2013 Mar;
45(4):428-32, 432e1.
PMID: 23455637
We report the results of an association study of melanoma that is based on the genome-wide imputation of the genotypes of 1,353 cases and 3,566 controls of European origin conducted...
10.
Stacey S, Sulem P, Jonasdottir A, Masson G, Gudmundsson J, Gudbjartsson D, et al.
Nat Genet
. 2011 Sep;
43(11):1098-103.
PMID: 21946351
To identify new risk variants for cutaneous basal cell carcinoma, we performed a genome-wide association study of 16 million SNPs identified through whole-genome sequencing of 457 Icelanders. We imputed genotypes...