John W Wallis
Overview
Explore the profile of John W Wallis including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
8818
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Recent Articles
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Chen K, Navin N, Wang Y, Schmidt H, Wallis J, Niu B, et al.
Genome Biol
. 2013 Aug;
14(8):R87.
PMID: 23972288
Producing gene fusions through genomic structural rearrangements is a major mechanism for tumor evolution. Therefore, accurately detecting gene fusions and the originating rearrangements is of great importance for personalized cancer...
3.
Ley T, Miller C, Ding L, Raphael B, Mungall A, Robertson A, et al.
N Engl J Med
. 2013 May;
368(22):2059-74.
PMID: 23634996
Background: Many mutations that contribute to the pathogenesis of acute myeloid leukemia (AML) are undefined. The relationships between patterns of mutations and epigenetic phenotypes are not yet clear. Methods: We...
4.
Gutmann D, McLellan M, Hussain I, Wallis J, Fulton L, Fulton R, et al.
Genome Res
. 2012 Dec;
23(3):431-9.
PMID: 23222849
Low-grade brain tumors (pilocytic astrocytomas) arising in the neurofibromatosis type 1 (NF1) inherited cancer predisposition syndrome are hypothesized to result from a combination of germline and acquired somatic NF1 tumor...
5.
Welch J, Ley T, Link D, Miller C, Larson D, Koboldt D, et al.
Cell
. 2012 Jul;
150(2):264-78.
PMID: 22817890
Most mutations in cancer genomes are thought to be acquired after the initiating event, which may cause genomic instability and drive clonal evolution. However, for acute myeloid leukemia (AML), normal...
6.
Ellis M, Ding L, Shen D, Luo J, Suman V, Wallis J, et al.
Nature
. 2012 Jun;
486(7403):353-60.
PMID: 22722193
To correlate the variable clinical features of oestrogen-receptor-positive breast cancer with somatic alterations, we studied pretreatment tumour biopsies accrued from patients in two studies of neoadjuvant aromatase inhibitor therapy by...
7.
Chen K, Wallis J, Kandoth C, Kalicki-Veizer J, Mungall K, Mungall A, et al.
Bioinformatics
. 2012 May;
28(14):1923-4.
PMID: 22563071
Unlabelled: Despite recent progress, computational tools that identify gene fusions from next-generation whole transcriptome sequencing data are often limited in accuracy and scalability. Here, we present a software package, BreakFusion...
8.
Ding L, Ley T, Larson D, Miller C, Koboldt D, Welch J, et al.
Nature
. 2012 Jan;
481(7382):506-10.
PMID: 22237025
Most patients with acute myeloid leukaemia (AML) die from progressive disease after relapse, which is associated with clonal evolution at the cytogenetic level. To determine the mutational spectrum associated with...
9.
Wendl M, Wallis J, Lin L, Kandoth C, Mardis E, Wilson R, et al.
Bioinformatics
. 2011 Apr;
27(12):1595-602.
PMID: 21498403
Motivation: The expansion of cancer genome sequencing continues to stimulate development of analytical tools for inferring relationships between somatic changes and tumor development. Pathway associations are especially consequential, but existing...
10.
Ding L, Ellis M, Li S, Larson D, Chen K, Wallis J, et al.
Nature
. 2010 Apr;
464(7291):999-1005.
PMID: 20393555
Massively parallel DNA sequencing technologies provide an unprecedented ability to screen entire genomes for genetic changes associated with tumour progression. Here we describe the genomic analyses of four DNA samples...