John V Pearson
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Explore the profile of John V Pearson including associated specialties, affiliations and a list of published articles.
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105
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17373
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Recent Articles
1.
Johnson E, Lai D, Miller A, Hatoum A, Deak J, Balbona J, et al.
medRxiv
. 2025 Feb;
PMID: 39974067
Genetic research on nicotine dependence has utilized multiple assessments that are in weak agreement. We conducted a genome-wide association study of nicotine dependence defined using the Diagnostic and Statistical Manual...
2.
Newell F, Pires da Silva I, Johansson P, Menzies A, Wilmott J, Addala V, et al.
Cancer Cell
. 2025 Feb;
43(3):563.
PMID: 39919735
No abstract available.
3.
Liu L, Zhang J, Wood S, Newell F, Leonard C, Koufariotis L, et al.
BMC Genomics
. 2024 Sep;
25(1):898.
PMID: 39350042
Background: Lung cancer is a heterogeneous disease and the primary cause of cancer-related mortality worldwide. Somatic mutations, including large structural variants, are important biomarkers in lung cancer for selecting targeted...
4.
Brosda S, Aoude L, Bonazzi V, Patel K, Lonie J, Belle C, et al.
Genome Med
. 2024 Jul;
16(1):90.
PMID: 39020404
Background: Oesophageal adenocarcinoma (OAC) is a highly heterogeneous cancer with poor survival. Standard curative treatment is chemotherapy with or without radiotherapy followed by oesophagectomy. Genomic heterogeneity is a feature of...
5.
Fielding D, Lakis V, Dalley A, Chittoory H, Newell F, Koufariotis L, et al.
Cancers (Basel)
. 2024 Feb;
16(4).
PMID: 38398180
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is often the only source of tumor tissue from patients with advanced, inoperable lung cancer. EBUS-TBNA aspirates are used for the diagnosis, staging, and...
6.
Fielding D, Dalley A, Singh M, Nandakumar L, Lakis V, Chittoory H, et al.
Front Oncol
. 2023 Nov;
13:1259882.
PMID: 37927461
Introduction: Tumour Mutation Burden (TMB) is a potential biomarker for immune cancer therapies. Here we investigated parameters that might affect TMB using duplicate cytology smears obtained from endobronchial ultrasound transbronchial...
7.
Addala V, Newell F, Pearson J, Redwood A, Robinson B, Creaney J, et al.
Nat Rev Clin Oncol
. 2023 Nov;
21(1):28-46.
PMID: 37907723
Cancer immunogenomics is an emerging field that bridges genomics and immunology. The establishment of large-scale genomic collaborative efforts along with the development of new single-cell transcriptomic techniques and multi-omics approaches...
8.
Davidson A, Dressel U, Norris S, Canson D, Glubb D, Fortuno C, et al.
Genome Med
. 2023 Sep;
15(1):74.
PMID: 37723522
Background: Many families and individuals do not meet criteria for a known hereditary cancer syndrome but display unusual clusters of cancers. These families may carry pathogenic variants in cancer predisposition...
9.
Tran K, Addala V, Johnston R, Lovell D, Bradley A, Koufariotis L, et al.
Nat Commun
. 2023 Sep;
14(1):5758.
PMID: 37717006
Cells within the tumour microenvironment (TME) can impact tumour development and influence treatment response. Computational approaches have been developed to deconvolve the TME from bulk RNA-seq. Using scRNA-seq profiling from...
10.
Aoude L, Brosda S, Ng J, Lonie J, Belle C, Patel K, et al.
J Mol Diagn
. 2023 Aug;
25(10):771-781.
PMID: 37544359
For patients with BRAF wild-type stage III and IV melanoma, there is an urgent clinical need to identify prognostic biomarkers and biomarkers predictive of treatment response. Circulating tumor DNA (ctDNA)...