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John T O Brien

Explore the profile of John T O Brien including associated specialties, affiliations and a list of published articles. Areas
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Articles 6
Citations 88
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Recent Articles
1.
Dounavi M, McKiernan E, Langsen M, Gregory S, Muniz-Terrera G, Prats-Sedano M, et al.
Brain Commun . 2024 May; 6(3):fcae138. PMID: 38779354
Changes in the brain's physiology in Alzheimer's disease are thought to occur early in the disease's trajectory. In this study our aim was to investigate the brain's neurochemical profile in...
2.
Malpetti M, Jones P, Cope T, Holland N, Naessens M, Rouse M, et al.
Ann Neurol . 2022 Nov; 93(1):142-154. PMID: 36321699
Objective: Synaptic loss is an early feature of neurodegenerative disease models, and is severe in post mortem clinical studies, including frontotemporal dementia. Positron emission tomography (PET) with radiotracers that bind...
3.
Dounavi M, Mak E, Wells K, Ritchie K, Ritchie C, Su L, et al.
Neurobiol Aging . 2020 Apr; 91:36-44. PMID: 32311609
The hippocampus is one of the first regions to demonstrate atrophy during the prodromal stage of Alzheimer's disease. Volumetric analysis of its individual subfields could provide biomarkers with higher sensitivity...
4.
Fantoni E, Chalkidou A, O Brien J, Farrar G, Hammers A
J Alzheimers Dis . 2018 Apr; 63(2):783-796. PMID: 29689725
Background: Amyloid PET (aPET) imaging could improve patient outcomes in clinical practice, but the extent of impact needs quantification. Objective: To provide an aggregated quantitative analysis of the value added...
5.
Stylianou M, Murphy N, Peraza L, Graziadio S, Cromarty R, Killen A, et al.
Clin Neurophysiol . 2018 Apr; 129(6):1209-1220. PMID: 29656189
Objective: We investigated for quantitative EEG (QEEG) differences between Alzheimer's disease (AD), dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) patients and healthy controls, and for QEEG signatures...
6.
Mukaetova-Ladinska E, Abdell-All Z, Andrade J, da Silva J, Boksha I, Burbaeva G, et al.
Curr Alzheimer Res . 2018 Apr; 15(9):800-808. PMID: 29623842
Background: Cerebrospinal fluid (CSF) measures of tau and amyloid proteins have now been largely accepted to be a diagnostic tool to aid the clinical diagnosis of Alzheimer's disease (AD), but...