John S Markowitz
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Explore the profile of John S Markowitz including associated specialties, affiliations and a list of published articles.
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106
Citations
1748
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Recent Articles
1.
Melchert P, Zhang Q, Markowitz J
Chem Biol Interact
. 2024 Sep;
403:111247.
PMID: 39299374
Kratom (Mitragyna Speciosa Korth.) is an indigenous tree native to Southeast Asia whose leaves have been traditionally ingested as a tea and has seen its popularity increase in the United...
2.
Davis C, Markowitz J, Squeglia L, Ellingson J, McRae-Clark A, Gray K, et al.
Addict Behav
. 2024 Feb;
153():107996.
PMID: 38394959
Early positive subjective effects of cannabis predict the development of cannabis use disorder (CUD). Genetic factors, such as the presence of cytochrome P450 genetic variants that are associated with reduced...
3.
Zhang Q, Melchert P, Markowitz J
Med Cannabis Cannabinoids
. 2024 Jan;
7(1):1-9.
PMID: 38292071
Introduction: Cannabidiol (CBD) is a widely utilized nonpsychoactive cannabinoid available as a prescriptive drug treatment and over-the-counter supplement. In humans, CBD is metabolized and forms the major active metabolite 7-hydroxy-cannabidiol...
4.
Melchert P, Zhang Q, Mukhopadhyay S, Kanumuri S, McCurdy C, Markowitz J
Chem Biol Interact
. 2023 Sep;
384:110715.
PMID: 37716419
Kratom, (Mitragyna Speciosa Korth.) is a plant indigenous to Southeast Asia whose leaves are cultivated for a variety of medicinal purposes and mostly consumed as powders or tea in the...
5.
Markowitz J, de Faria L, Zhang Q, Melchert P, Frye R, Klee B, et al.
Med Cannabis Cannabinoids
. 2022 Dec;
5(1):199-206.
PMID: 36467779
Introduction: Cannabidiol (CBD) is a widely utilized nonpsychoactive cannabinoid available as an over-the-counter supplement, a component of medical cannabis, and a prescriptive treatment of childhood epilepsies. In vitro studies suggest...
6.
Qian Y, Melchert P, Markowitz J
Chem Biol Interact
. 2022 Oct;
368:110228.
PMID: 36283465
Beclomethasone dipropionate (BDP) is an inhaled glucocorticoid used for maintenance treatment of asthma in adults and children. BDP is a prodrug activated in lung when hydrolyzed to its major active...
7.
Zhang Q, Melchert P, Markowitz J
Chem Biol Interact
. 2022 Aug;
365:110097.
PMID: 35964681
Remdesivir (RDV, Veklury®) is an FDA-approved prodrug for the treatment of hospitalized patients with COVID-19. Recent in vitro studies have indicated that human carboxylesterase 1 (CES1) is the major metabolic...
8.
Rezai M, Ahangarkani F, Hill A, Ellis L, Mirchandani M, Davoudi A, et al.
Front Med (Lausanne)
. 2022 Jul;
9:919708.
PMID: 35783616
Background: Ivermectin which was widely considered as a potential treatment for COVID-19, showed uncertain clinical benefit in many clinical trials. Performing large-scale clinical trials to evaluate the effectiveness of this...
9.
Markowitz J, Melchert P
Child Adolesc Psychiatr Clin N Am
. 2022 Jun;
31(3):393-416.
PMID: 35697392
The psychostimulants-amphetamine and methylphenidate-have been in clinical use for well more than 60 years. In general, both stimulants are rapidly absorbed with relatively poor bioavailability and short half-lives. The pharmacokinetics...
10.
Qian Y, Markowitz J
Drug Metab Dispos
. 2022 May;
50(7):968-979.
PMID: 35512806
The use of cannabis products has increased substantially. Cannabis products have been perceived and investigated as potential treatments for attention-deficit/hyperactivity disorder (ADHD). Accordingly, co-administration of cannabis products and methylphenidate (MPH),...