John R Lloyd
Overview
Explore the profile of John R Lloyd including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
427
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0
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Recent Articles
1.
Hu Z, Rolt A, Hu X, Ma C, Le D, Park S, et al.
Cell Chem Biol
. 2020 May;
27(7):780-792.e5.
PMID: 32386595
Chlorcyclizine (CCZ) is a potent hepatitis C virus (HCV) entry inhibitor, but its molecular mechanism is unknown. Here, we show that CCZ directly targets the fusion peptide of HCV E1...
2.
Lloyd J, Jayasekara P, Jacobson K
Anal Methods
. 2016 Mar;
8(2):263-269.
PMID: 26997980
Generation 3 (G3) PAMAM dendrimers are symmetrical, highly branched polymers widely reported in the scientific literature as therapeutic agents themselves or as carrier scaffolds for various therapeutic agents. A large...
3.
Jagodinsky J, Sulima A, Cao Y, Poprawski J, Blackman B, Lloyd J, et al.
J Biol Inorg Chem
. 2015 Sep;
20(7):1081-95.
PMID: 26323351
The platinum drugs cisplatin, carboplatin, and oxaliplatin are highly utilized in the clinic and as a consequence have been extensively studied in the laboratory setting, sometimes by generating fluorophore-tagged analogs....
4.
Hall M, Telma K, Chang K, Lee T, Madigan J, Lloyd J, et al.
Cancer Res
. 2014 May;
74(14):3913-22.
PMID: 24812268
The platinum drugs cisplatin, carboplatin, and oxaliplatin are highly utilized in the clinic and as a consequence are extensively studied in the laboratory setting. In this study, we examined the...
5.
Kumar P, Arora K, Lloyd J, Lee I, Nair V, Fischer E, et al.
Mol Microbiol
. 2012 Aug;
86(2):367-81.
PMID: 22906310
Carbapenems such as meropenem are being investigated for their potential therapeutic utility against highly drug-resistant tuberculosis. These β-lactams target the transpeptidases that introduce interpeptide cross-links into bacterial peptidoglycan thereby controlling...
6.
Keffer J, Hammill J, Lloyd J, Plaza A, Wipf P, Bewley C
Mar Drugs
. 2012 Jul;
10(5):1103-1125.
PMID: 22822360
Drug-resistant Staphylococcus aureus is a continuing public health concern, both in the hospital and community settings. Antibacterial compounds that possess novel structural scaffolds and are effective against multiple S. aureus...
7.
Cheruku P, Plaza A, Lauro G, Keffer J, Lloyd J, Bifulco G, et al.
J Med Chem
. 2011 Dec;
55(2):735-42.
PMID: 22168797
The discovery, structure elucidation, and solid-phase synthesis of namalide, a marine natural product, are described. Namalide is a cyclic tetrapeptide; its macrocycle is formed by only three amino acids, with...
8.
Lloyd J, Hess S
J Am Soc Mass Spectrom
. 2010 Sep;
21(12):2051-61.
PMID: 20869880
Fundamental studies have greatly improved our understanding of electrospray, including the underlying electrochemical reactions. Generally regarded as disadvantageous, we have recently shown that corona discharge (CD) can be used as...
9.
Plaza A, Keffer J, Bifulco G, Lloyd J, Bewley C
J Am Chem Soc
. 2010 Jun;
132(26):9069-77.
PMID: 20536175
Eight new antimicrobial natural products named chrysophaentins A-H belonging to a new structural class have been isolated from the marine chrysophyte alga Chrysophaeum taylori. Their structures were determined by extensive...
10.
Hu J, Wang Y, Zhang X, Lloyd J, Li J, Karpiak J, et al.
Nat Chem Biol
. 2010 Jun;
6(7):541-8.
PMID: 20512139
The interaction of G protein-coupled receptors (GPCRs) with heterotrimeric G proteins represents one of the most fundamental biological processes. However, the molecular architecture of the GPCR-G protein complex remains poorly...