John P McDonald
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Explore the profile of John P McDonald including associated specialties, affiliations and a list of published articles.
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34
Citations
718
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Recent Articles
11.
Walsh E, Henrikus S, Vaisman A, Makiela-Dzbenska K, Armstrong T, Lazowski K, et al.
DNA Repair (Amst)
. 2019 Sep;
84:102685.
PMID: 31543434
pol V (RumA'B) is a low-fidelity polymerase that promotes considerably higher levels of spontaneous "SOS-induced" mutagenesis than the related E. coli pol V (UmuD'C). The molecular basis for the enhanced...
12.
Kreisel K, Engqvist M, Kalm J, Thompson L, Bostrom M, Navarrete C, et al.
Nucleic Acids Res
. 2019 Jan;
47(5):2425-2435.
PMID: 30597049
DNA polymerase η (pol η) is best known for its ability to bypass UV-induced thymine-thymine (T-T) dimers and other bulky DNA lesions, but pol η also has other cellular roles....
13.
Gonzalez M, Huston D, McLenigan M, McDonald J, Garcia A, Borden K, et al.
DNA Repair (Amst)
. 2018 Dec;
73:99-109.
PMID: 30581075
The integrating conjugative element ICE391 (formerly known as IncJ R391) harbors an error-prone DNA polymerase V ortholog, polV, encoded by the ICE391 rumAB operon. polV and its orthologs have previously...
14.
Henrikus S, Wood E, McDonald J, Cox M, Woodgate R, Goodman M, et al.
PLoS Genet
. 2018 Jan;
14(1):e1007161.
PMID: 29351274
In Escherichia coli, damage to the chromosomal DNA induces the SOS response, setting in motion a series of different DNA repair and damage tolerance pathways. DNA polymerase IV (pol IV)...
15.
Frank E, McLenigan M, McDonald J, Huston D, Mead S, Woodgate R
DNA Repair (Amst)
. 2017 Sep;
58:47-51.
PMID: 28865289
The cDNA encoding human DNA polymerase ι (POLI) was cloned in 1999. At that time, it was believed that the POLI gene encoded a protein of 715 amino acids. Advances...
16.
Frank E, McDonald J, Yang W, Woodgate R
DNA Repair (Amst)
. 2017 Jan;
50:71-76.
PMID: 28077247
In 2003, we reported that 129-derived strains of mice carry a naturally occurring nonsense mutation at codon 27 of the Poli gene that would produce a polι peptide of just...
17.
Goodman M, McDonald J, Jaszczur M, Woodgate R
DNA Repair (Amst)
. 2016 May;
44:42-50.
PMID: 27236212
It is now close to 40 years since the isolation of non-mutable umu/uvm strains of Escherichia coli and the realization that damage induced mutagenesis in E.coli is not a passive...
18.
Vaisman A, McDonald J, Woodgate R
EcoSal Plus
. 2015 Oct;
5(1).
PMID: 26442823
All living organisms are continually exposed to agents that damage their DNA, which threatens the integrity of their genome. As a consequence, cells are equipped with a plethora of DNA...
19.
Donigan K, Cerritelli S, McDonald J, Vaisman A, Crouch R, Woodgate R
DNA Repair (Amst)
. 2015 Sep;
35:1-12.
PMID: 26340535
DNA polymerase η (pol η) is best characterized for its ability to perform accurate and efficient translesion DNA synthesis (TLS) through cyclobutane pyrimidine dimers (CPDs). To ensure accurate bypass the...
20.
Robinson A, McDonald J, Caldas V, Patel M, Wood E, Punter C, et al.
PLoS Genet
. 2015 Aug;
11(8):e1005482.
PMID: 26317348
Spatial regulation is often encountered as a component of multi-tiered regulatory systems in eukaryotes, where processes are readily segregated by organelle boundaries. Well-characterized examples of spatial regulation are less common...