John M Pleinis
Overview
Explore the profile of John M Pleinis including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
128
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0
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Recent Articles
1.
Yarikipati P, Jonusaite S, Pleinis J, Dominicci Cotto C, Sanchez-Hernandez D, Morrison D, et al.
PLoS Genet
. 2023 Oct;
19(10):e1010975.
PMID: 37819975
WNK (With no Lysine [K]) kinases have critical roles in the maintenance of ion homeostasis and the regulation of cell volume. Their overactivation leads to pseudohypoaldosteronism type II (Gordon syndrome)...
2.
Balderas E, Eberhardt D, Lee S, Pleinis J, Sommakia S, Balynas A, et al.
Nat Commun
. 2022 Jun;
13(1):3532.
PMID: 35725853
No abstract available.
3.
Balderas E, Eberhardt D, Lee S, Pleinis J, Sommakia S, Balynas A, et al.
Nat Commun
. 2022 May;
13(1):2769.
PMID: 35589699
Calcium entering mitochondria potently stimulates ATP synthesis. Increases in calcium preserve energy synthesis in cardiomyopathies caused by mitochondrial dysfunction, and occur due to enhanced activity of the mitochondrial calcium uniporter...
4.
Schellinger J, Sun Q, Pleinis J, An S, Hu J, Mercenne G, et al.
Curr Biol
. 2022 Mar;
32(6):1429-1438.e6.
PMID: 35303418
Central pacemaker neurons regulate circadian rhythms and undergo diurnal variation in electrical activity in mammals and flies. Circadian variation in the intracellular chloride concentration of mammalian pacemaker neurons has been...
5.
Pleinis J, Norrell L, Akella R, Humphreys J, He H, Sun Q, et al.
Am J Physiol Cell Physiol
. 2021 Jan;
320(5):C703-C721.
PMID: 33439774
With no lysine (K) (WNK) kinases regulate epithelial ion transport in the kidney to maintain homeostasis of electrolyte concentrations and blood pressure. Chloride ion directly binds WNK kinases to inhibit...
6.
Talsness D, Owings K, Coelho E, Mercenne G, Pleinis J, Partha R, et al.
Elife
. 2020 Dec;
9.
PMID: 33315011
N-Glycanase 1 (NGLY1) is a cytoplasmic deglycosylating enzyme. Loss-of-function mutations in the gene cause NGLY1 deficiency, which is characterized by developmental delay, seizures, and a lack of sweat and tears....
7.
Perry N, Kaoud T, Ortega O, Kaya A, Marcus D, Pleinis J, et al.
Proc Natl Acad Sci U S A
. 2018 Dec;
116(3):810-815.
PMID: 30591558
Scaffold proteins tether and orient components of a signaling cascade to facilitate signaling. Although much is known about how scaffolds colocalize signaling proteins, it is unclear whether scaffolds promote signal...
8.
Sun Q, Wu Y, Jonusaite S, Pleinis J, Humphreys J, He H, et al.
J Am Soc Nephrol
. 2018 Apr;
29(5):1449-1461.
PMID: 29602832
With No Lysine kinase (WNK) signaling regulates mammalian renal epithelial ion transport to maintain electrolyte and BP homeostasis. Our previous studies showed a conserved role for WNK in the regulation...
9.
Pleinis J, Davis C, Cantrell C, Qiu D, Zhan X
Protein Expr Purif
. 2017 Jan;
132:34-43.
PMID: 28082061
Apoptosis signal-regulating kinase I (ASK1) is a mitogen-activated protein kinase kinase kinase (MAP3K) that activates the downstream MAP kinase kinases (MKKs) from two MAP kinase cascades: c-Jun N-terminal kinase (JNK)...