John M Levorse
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Explore the profile of John M Levorse including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
591
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0
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Recent Articles
1.
Stewart K, Abdusselamoglu M, Tierney M, Gola A, Hur Y, Gonzales K, et al.
Nature
. 2024 Aug;
633(8029):407-416.
PMID: 39169186
Billions of cells are eliminated daily from our bodies. Although macrophages and dendritic cells are dedicated to migrating and engulfing dying cells and debris, many epithelial and mesenchymal tissue cells...
2.
Stewart K, Gonzales K, Yuan S, Tierney M, Bonny A, Yang Y, et al.
bioRxiv
. 2023 Jun;
PMID: 37293114
Macrophages and dendritic cells have long been appreciated for their ability to migrate to and engulf dying cells and debris, including some of the billions of cells that are naturally...
3.
Yuan S, Stewart K, Yang Y, Abdusselamoglu M, Parigi S, Feinberg T, et al.
Nature
. 2022 Nov;
612(7940):555-563.
PMID: 36450983
Squamous cell carcinomas are triggered by marked elevation of RAS-MAPK signalling and progression from benign papilloma to invasive malignancy. At tumour-stromal interfaces, a subset of tumour-initiating progenitors, the cancer stem...
4.
Zhou X, Zhang Z, Shin M, Horwitz S, Levorse J, Zhu L, et al.
Hypertension
. 2013 Jun;
62(2):288-94.
PMID: 23753405
The renal outer medullary potassium channel (ROMK, KCNJ1) mediates potassium recycling and facilitates sodium reabsorption through the Na(+)/K(+)/2Cl(-) cotransporter in the loop of Henle and potassium secretion at the cortical...
5.
Lin H, Chen D, Shen Z, Zhu L, Ouyang X, Vongs A, et al.
PLoS One
. 2013 Jan;
8(1):e54480.
PMID: 23336002
Diacylglycerol acyltransferase-1 (DGAT1) is a potential therapeutic target for treatment of obesity and related metabolic diseases. However, the degree of DGAT1 inhibition required for metabolic benefits is unclear. Here we...
6.
Moran J, Shifley E, Levorse J, Mani S, Ostmann K, Perez-Balaguer A, et al.
Dev Dyn
. 2009 May;
238(7):1803-12.
PMID: 19479951
Tight regulation of Notch pathway signaling is important in many aspects of embryonic development. Notch signaling can be modulated by expression of fringe genes, encoding glycosyltransferases that modify EGF repeats...
7.
Morgan S, Lee H, Relaix F, Sandell L, Levorse J, Loeken M
Mech Dev
. 2008 Aug;
125(9-10):757-67.
PMID: 18672055
During neural tube closure, Pax3 is required to inhibit p53-dependent apoptosis. Pax3 is also required for migration of cardiac neural crest (CNC) from the neural tube to the heart and...
8.
Mancini-DiNardo D, Steele S, Levorse J, Ingram R, Tilghman S
Genes Dev
. 2006 May;
20(10):1268-82.
PMID: 16702402
The imprinted gene cluster at the telomeric end of mouse chromosome 7 contains a differentially methylated CpG island, KvDMR, that is required for the imprinting of multiple genes, including the...
9.
Carr M, Getek K, Levorse J, Schmidt J
Mamm Genome
. 2006 Jan;
17(1):5-13.
PMID: 16416086
The imprinted H19 gene produces a noncoding RNA of unknown function. Targeted and transgenic mouse mutations have shown that this RNA can be deleted and overexpressed without adverse effect. Yet...
10.
Katz D, Beer M, Levorse J, Tilghman S
Mol Cell Biol
. 2005 May;
25(10):3855-63.
PMID: 15870260
The imprinted expression of the H19 and Igf2 genes in the mouse is controlled by an imprinting control center (ICR) whose activity is regulated by parent-of-origin differences in methylation. The...