John M Humphreys
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Explore the profile of John M Humphreys including associated specialties, affiliations and a list of published articles.
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25
Citations
624
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Recent Articles
1.
Teixeira L, Akella R, Humphreys J, He H, Goldsmith E
Elife
. 2024 Nov;
12.
PMID: 39584807
Osmotic stress and chloride regulate the autophosphorylation and activity of the WNK1 and WNK3 kinase domains. The kinase domain of unphosphorylated WNK1 (uWNK1) is an asymmetric dimer possessing water molecules...
2.
Modeling the 2014-2015 Vesicular Stomatitis Outbreak in the United States Using an SEIR-SEI Approach
Humphreys J, Pelzel-McCluskey A, Shults P, Velazquez-Salinas L, Bertram M, McGregor B, et al.
Viruses
. 2024 Aug;
16(8).
PMID: 39205289
Vesicular stomatitis (VS) is a vector-borne livestock disease caused by the vesicular stomatitis New Jersey virus (VSNJV). This study presents the first application of an SEIR-SEI compartmental model to analyze...
3.
Humphreys J, Shults P, Velazquez-Salinas L, Bertram M, Pelzel-McCluskey A, Pauszek S, et al.
Viruses
. 2024 Jul;
16(7).
PMID: 39066280
We conducted an integrative analysis to elucidate the spatial epidemiological patterns of the Vesicular Stomatitis New Jersey virus (VSNJV) during the 2014-15 epizootic cycle in the United States (US). Using...
4.
Teixeira L, Akella R, Humphreys J, He H, Goldsmith E
bioRxiv
. 2023 Sep;
PMID: 37693587
Osmotic stress and chloride regulate the autophosphorylation and activity of the WNK1 and WNK3 kinase domains. The kinase domain of unphosphorylated WNK1 (uWNK1) is an asymmetric dimer possessing water molecules...
5.
Humphreys J, Teixeira L, Akella R, He H, Kannangara A, Sekulski K, et al.
Mol Biol Cell
. 2023 Aug;
34(11):ar109.
PMID: 37585288
Previous study has demonstrated that the WNK kinases 1 and 3 are direct osmosensors consistent with their established role in cell-volume control. WNK kinases may also be regulated by hydrostatic...
6.
Wilson E, Cousins S, Etter D, Humphreys J, Roloff G, Carter N
Ecol Evol
. 2023 May;
13(5):e10083.
PMID: 37214615
Climate change and habitat loss are recognized as important drivers of shifts in wildlife species' geographic distributions. While often considered independently, there is considerable overlap between these drivers, and understanding...
7.
Chlebowicz J, Akella R, Humphreys J, He H, Kannangara A, Wei S, et al.
Drug Des Devel Ther
. 2023 Jan;
17:93-105.
PMID: 36712947
Introduction: WNK [with no lysine (K)] kinases are serine/threonine kinases associated with familial hyperkalemic hypertension (FHHt). WNKs are therapeutic targets for blood pressure regulation, stroke and several cancers including triple...
8.
Holcomb K, Mathis S, Staples J, Fischer M, Barker C, Beard C, et al.
Parasit Vectors
. 2023 Jan;
16(1):11.
PMID: 36635782
Background: West Nile virus (WNV) is the leading cause of mosquito-borne illness in the continental USA. WNV occurrence has high spatiotemporal variation, and current approaches to targeted control of the...
9.
Humphreys J, Pelzel-McCluskey A, Cohnstaedt L, McGregor B, Hanley K, Hudson A, et al.
Viruses
. 2021 Sep;
13(9).
PMID: 34578392
Mosquito-borne West Nile virus (WNV) is the causative agent of West Nile disease in humans, horses, and some bird species. Since the initial introduction of WNV to the United States...
10.
Humphreys J, Young K, Cohnstaedt L, Hanley K, Peters D
Viruses
. 2021 Jun;
13(5).
PMID: 34070039
West Nile virus (WNV) is the most common arthropod-borne virus (arbovirus) in the United States (US) and is the leading cause of viral encephalitis in the country. The virus has...