John M Higgins
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Explore the profile of John M Higgins including associated specialties, affiliations and a list of published articles.
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63
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4662
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Recent Articles
1.
Tozzo V, Petherbridge R, James K, Hsu S, Michalopoulos C, Foy B, et al.
medRxiv
. 2025 Feb;
PMID: 39990572
Objectives: Pregnancy alters hematologic state as measured by complete blood counts (CBC), but the longitudinal changes in CBC indices that define healthy pregnancies are not well established. Our objectives were...
2.
Foy B, Carlson J, Aguirre A, Higgins J
Nat Commun
. 2025 Jan;
16(1):1113.
PMID: 39875373
Complete blood count indices and their ratios are associated with adverse clinical outcomes for many acute illnesses, but the mechanisms generating these associations are not fully understood. Recent identification of...
3.
Yonker L, Badaki-Makun O, Alvarez-Carcamo B, Cross C, Okuducu Y, Appleman L, et al.
Shock
. 2025 Jan;
63(3):385-389.
PMID: 39749928
Background: Early, accurate determination of disease severity in an emergency setting is paramount for improving patient outcomes and healthcare costs. Monocyte anisocytosis, quantified as monocyte distribution width (MDW), has been...
4.
Foy B, Petherbridge R, Roth M, Zhang C, De Souza D, Mow C, et al.
Nature
. 2024 Dec;
637(8045):430-438.
PMID: 39663453
The complete blood count (CBC) is an important screening tool for healthy adults and a common test at periodic exams. However, results are usually interpreted relative to one-size-fits-all reference intervals,...
5.
Tozzo V, Genco M, Omololu S, Mow C, Patel H, Patel C, et al.
Diabetes Care
. 2024 Feb;
47(3):460-466.
PMID: 38394636
Objective: To examine the accuracy of different periods of continuous glucose monitoring (CGM), hemoglobin A1c (HbA1c), and their combination for estimating mean glycemia over 90 days (AG90). Research Design And...
6.
Foy B, Petherbridge R, Roth M, Mow C, Patel H, Patel C, et al.
medRxiv
. 2023 Oct;
PMID: 37808854
The complete blood count is an important screening tool for healthy adults and is the most commonly ordered test at periodic physical exams. However, results are usually interpreted relative to...
7.
De Souza D, Hebert N, Esrick E, Ciuculescu M, Archer N, Armant M, et al.
Nat Commun
. 2023 Sep;
14(1):5850.
PMID: 37730674
We previously reported initial clinical results of post-transcriptional gene silencing of BCL11A expression (NCT03282656) reversing the fetal to adult hemoglobin switch. A goal of this approach is to increase fetal...
8.
Zhang L, Tozzo V, Higgins J, Ranganath R
Proc Mach Learn Res
. 2023 Aug;
162:26559-26574.
PMID: 37645424
Permutation invariant neural networks are a promising tool for making predictions from sets. However, we show that existing permutation invariant architectures, Deep Sets and Set Transformer, can suffer from vanishing...
9.
Foy B, Stefely J, Bendapudi P, Hasserjian R, Al-Samkari H, Louissaint A, et al.
Blood Adv
. 2023 May;
7(16):4621-4630.
PMID: 37146262
Examination of red blood cell (RBC) morphology in peripheral blood smears can help diagnose hematologic diseases, even in resource-limited settings, but this analysis remains subjective and semiquantitative with low throughput....
10.
Qiang Y, Sissoko A, Liu Z, Dong T, Zheng F, Kong F, et al.
Proc Natl Acad Sci U S A
. 2023 Feb;
120(6):e2217607120.
PMID: 36730189
The spleen clears altered red blood cells (RBCs) from circulation, contributing to the balance between RBC formation (erythropoiesis) and removal. The splenic RBC retention and elimination occur predominantly in open...