John M Freund
Overview
Explore the profile of John M Freund including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
556
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0
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Recent Articles
1.
Stewart A, Kopper J, McKinney-Aguirre C, Veerasamy B, Sahoo D, Freund J, et al.
Front Vet Sci
. 2024 Nov;
11:1455262.
PMID: 39502947
Gastrointestinal disease is a leading cause of death in mature horses. A lack of modeling has impeded the development of novel therapeutics. The objectives of this study were to develop...
2.
McKinney-Aguirre C, Schaaf C, Goya-Jorge E, Freund J, Gonzalez L
Am J Physiol Gastrointest Liver Physiol
. 2024 Oct;
327(6):G783-G788.
PMID: 39404771
Intestinal ischemia and reperfusion injury (IRI) is a deadly and common condition. Death is associated with sepsis due to insufficient epithelial repair, requiring stem cell-driven regeneration, typically beginning 48 h...
3.
Stewart A, Schaaf C, Veerasammy B, Freund J, Gonzalez L
BMC Vet Res
. 2022 Dec;
18(1):445.
PMID: 36564773
Background: Equine intestinal epithelial stem cells (ISCs) serve as potential targets to treat horses with severe intestinal injury. The ability to isolate and store ISCs from intestinal biopsies creates an...
4.
Stewart A, Schaaf C, Luff J, Freund J, Becker T, Tufts S, et al.
Am J Physiol Gastrointest Liver Physiol
. 2021 Sep;
321(5):G588-G602.
PMID: 34549599
Intestinal ischemia is a life-threatening emergency with mortality rates of 50%-80% due to epithelial cell death and resultant barrier loss. Loss of the epithelial barrier occurs in conditions including intestinal...
5.
Singh A, Hung Y, Shanahan M, Kanke M, Bonfini A, Dame M, et al.
Cell Mol Gastroenterol Hepatol
. 2019 Nov;
9(3):447-464.
PMID: 31756561
Background & Aims: The enteroendocrine cell (EEC) lineage is important for intestinal homeostasis. It was recently shown that EEC progenitors contribute to intestinal epithelial growth and renewal, but the underlying...
6.
Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia
Stewart A, Freund J, Blikslager A, Gonzalez L
J Vis Exp
. 2018 Jun;
(135).
PMID: 29863654
Intestinal ischemia remains a major cause of morbidity and mortality in human and veterinary patients. Many disease processes result in intestinal ischemia, when the blood supply and therefore oxygen is...
7.
Kumar M, Kumar M, Freund J, Dillon G
J Pharmacol Exp Ther
. 2017 Jun;
362(3):395-404.
PMID: 28642232
The muscle relaxant carisoprodol has recently been controlled at the federal level as a Schedule IV drug due to its high abuse potential and consequences of misuse, such as withdrawal...
8.
Wolf M, Carruthers C, Dearth C, Crapo P, Huber A, Burnsed O, et al.
J Biomed Mater Res A
. 2013 Jul;
102(1):234-46.
PMID: 23873846
Surgical mesh devices composed of synthetic materials are commonly used for ventral hernia repair. These materials provide robust mechanical strength and are quickly incorporated into host tissue; factors that contribute...
9.
Hong Y, Takanari K, Amoroso N, Hashizume R, Brennan-Pierce E, Freund J, et al.
Tissue Eng Part C Methods
. 2011 Sep;
18(2):122-32.
PMID: 21933017
A biodegradable elastomeric scaffold was created by electrospinning a mixed solution of poly(ester urethane)urea (PEUU) and porcine dermal extracellular matrix (dECM) digest, with PEUU included to provide elasticity, flexibility, and...
10.
Agrawal V, Tottey S, Johnson S, Freund J, Siu B, Badylak S
Tissue Eng Part A
. 2011 May;
17(19-20):2435-43.
PMID: 21563860
Biologic scaffolds composed of extracellular matrix (ECM) have been used successfully in preclinical models and humans for constructive remodeling of functional, site-appropriate tissue after injury. The mechanisms underlying ECM-mediated constructive...