Cecilia R Schaaf
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Explore the profile of Cecilia R Schaaf including associated specialties, affiliations and a list of published articles.
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11
Citations
24
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Recent Articles
1.
McKinney-Aguirre C, Schaaf C, Goya-Jorge E, Freund J, Gonzalez L
Am J Physiol Gastrointest Liver Physiol
. 2024 Oct;
327(6):G783-G788.
PMID: 39404771
Intestinal ischemia and reperfusion injury (IRI) is a deadly and common condition. Death is associated with sepsis due to insufficient epithelial repair, requiring stem cell-driven regeneration, typically beginning 48 h...
2.
Enhancing the Efficacy of HIPEC Through Bromelain: A Preclinical Investigation in Appendiceal Cancer
Wajih N, Erali R, Forsythe S, Schaaf C, Shen P, Levine E, et al.
Ann Surg Oncol
. 2024 May;
31(8):5377-5389.
PMID: 38704503
Introduction: Appendiceal cancer (AC) excessive mucin production is a barrier to heated intraperitoneal chemotherapy (HIPEC) drug delivery. Bromelain is a pineapple stem extract with mucolytic properties. We explored bromelain treatment...
3.
Nomdedeu-Sancho G, Gorkun A, Mahajan N, Willson K, Schaaf C, Votanopoulos K, et al.
Cancers (Basel)
. 2023 Dec;
15(24).
PMID: 38136325
Melanoma is responsible for the majority of skin cancer-related fatalities. Immune checkpoint inhibitor (ICI) treatments have revolutionized the management of the disease by significantly increasing patient survival rates. However, a...
4.
Ludwig E, Abraham N, Schaaf C, McKinney C, Freund J, Stewart A, et al.
Am J Transplant
. 2023 Nov;
24(4):564-576.
PMID: 37918482
Intestinal transplantation (IT) is the final treatment option for intestinal failure. Static cold storage (CS) is the standard preservation method used for intestinal allografts. However, CS and subsequent transplantation induce...
5.
Forsythe S, Erali R, Edenhoffer N, Meeker W, Wajih N, Schaaf C, et al.
Sci Rep
. 2023 Jul;
13(1):11640.
PMID: 37468581
Peritoneal mesothelioma (PM) is a rare malignancy with poor prognosis, representing about 10-15% of all mesothelioma cases. Herein we apply PM patient-derived tumor organoids (PTOs) in elucidating personalized HIPEC responses...
6.
Schaaf C, Polkoff K, Carter A, Stewart A, Sheahan B, Freund J, et al.
FASEB J
. 2023 May;
37(6):e22975.
PMID: 37159340
Intestinal epithelial stem cells (ISCs) are responsible for intestinal epithelial barrier renewal; thereby, ISCs play a critical role in intestinal pathophysiology research. While transgenic ISC reporter mice are available, advanced...
7.
Veerasammy B, Gonzalez G, Baez-Ramos P, Schaaf C, Stewart A, Ludwig E, et al.
Equine Vet J
. 2023 Jan;
55(6):995-1002.
PMID: 36716291
Background: Intestinal epithelial stem cells (ISC) are responsible for epithelial regeneration and are critical to the intestine's ability to regain barrier function following injury. Evaluating ISC biomarker expression in cases...
8.
Stewart A, Schaaf C, Veerasammy B, Freund J, Gonzalez L
BMC Vet Res
. 2022 Dec;
18(1):445.
PMID: 36564773
Background: Equine intestinal epithelial stem cells (ISCs) serve as potential targets to treat horses with severe intestinal injury. The ability to isolate and store ISCs from intestinal biopsies creates an...
9.
Erali R, Forsythe S, Gironda D, Schaaf C, Wajih N, Soker S, et al.
J Gastrointest Cancer
. 2022 Nov;
54(3):712-719.
PMID: 36447085
Introduction: Treatment of colorectal cancer-derived peritoneal carcinomatosis (CRC-PC) is challenging due to cellular heterogeneity that exhibits variable degrees of resistance to systemic as well as intraperitoneal chemotherapy. Therefore, it is...
10.
Orthotopic Transplantation of the Full-length Porcine Intestine After Normothermic Machine Perfusion
Abraham N, Ludwig E, Schaaf C, Veerasammy B, Stewart A, McKinney C, et al.
Transplant Direct
. 2022 Oct;
8(11):e1390.
PMID: 36299444
Methods: Using a translational porcine model, we developed a device for intestinal perfusion. Intestinal samples were collected at the time of organ procurement, and after 6 h of machine perfusion...