John M Baumann
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Explore the profile of John M Baumann including associated specialties, affiliations and a list of published articles.
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8
Citations
68
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Recent Articles
1.
Schmitt J, Baumann J, Morgen M
Pharm Res
. 2022 Aug;
39(12):3223-3239.
PMID: 35986124
Spray dried dispersion particle size is a critical quality attribute that impacts bioavailability and manufacturability of the spray drying process and final dosage form. Substantial experimentation has been required to...
2.
Shepard K, Vodak D, Kuehl P, Revelli D, Zhou Y, Pluntze A, et al.
AAPS PharmSciTech
. 2021 Sep;
22(7):230.
PMID: 34467438
Local delivery of biotherapeutics to the lung holds great promise for treatment of lung diseases, but development of physically stable, biologically active dry powder formulations of large molecules for inhalation...
3.
Baumann J, Adam M, Wood J
Annu Rev Chem Biomol Eng
. 2021 Mar;
12:217-240.
PMID: 33781083
Spray drying is a versatile technology that has been applied widely in the chemical, food, and, most recently, pharmaceutical industries. This review focuses on engineering advances and the most significant...
4.
Mudie D, Stewart A, Biswas N, Brodeur T, Shepard K, Smith A, et al.
Mol Pharm
. 2020 Aug;
17(12):4463-4472.
PMID: 32835489
Amorphous solid dispersions (ASDs) can increase the bioavailability of drugs with poor aqueous solubility. However, concentration-sustaining dispersion polymers (CSPs) incorporated in ASDs can result in low drug loading and, therefore,...
5.
Shepard K, Dower A, Ekdahl A, Morgen M, Baumann J, Vodak D
Pharm Res
. 2020 Aug;
37(8):156.
PMID: 32737611
Purpose: The purpose of this work is to introduce solvent-assisted secondary drying, a method used to accelerate the residual solvent removal from spray dried materials. Spray-drying is used to manufacture...
6.
Mudie D, Buchanan S, Stewart A, Smith A, Shepard K, Biswas N, et al.
Int J Pharm X
. 2020 Mar;
2:100042.
PMID: 32154509
Although Amorphous Solid Dispersions (ASDs) effectively increase bioavailability, tablet mass can be high due to the large fraction of excipients needed to stabilize the amorphous drug in the solid state,...
7.
Gamble J, Ferreira A, Tobyn M, DiMemmo L, Martin K, Mathias N, et al.
Int J Pharm
. 2014 Feb;
465(1-2):210-7.
PMID: 24508807
The aim of this study was to investigate novel approaches to determine spray dried dispersion (SDD) specific particle characteristics through the use of imaging based technologies. The work demonstrates approaches...
8.
Dobry D, Settell D, Baumann J, Ray R, Graham L, Beyerinck R
J Pharm Innov
. 2010 Mar;
4(3):133-142.
PMID: 20234866
Solid amorphous dispersions are frequently used to improve the solubility and, thus, the bioavailability of poorly soluble active pharmaceutical ingredients (APIs). Spray-drying, a well-characterized pharmaceutical unit operation, is ideally suited...