John M Antos
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Explore the profile of John M Antos including associated specialties, affiliations and a list of published articles.
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25
Citations
862
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0
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Recent Articles
1.
Jackson S, Lee D, Blount J, Croney K, Ibershof J, Ceravolo C, et al.
J Biol Chem
. 2025 Mar;
:108382.
PMID: 40049417
Sortases are critical cysteine transpeptidases that facilitate the attachment of proteins to the cell wall in Gram-positive bacteria. These enzymes are potential targets for novel antibiotic development, and versatile tools...
2.
Kodama H, Lindblom K, Walkenhauer E, Antos J, Amacher J
Protein Sci
. 2024 Nov;
33(12):e5212.
PMID: 39548757
Bacterial sortases are a family of cysteine transpeptidases in Gram-positive bacteria of which sortase A (SrtA) enzymes are responsible for ligating proteins to the peptidoglycan layer of the cell surface....
3.
Amacher J, Antos J
Trends Biochem Sci
. 2024 May;
49(7):596-610.
PMID: 38692993
Sortase enzymes are critical cysteine transpeptidases on the surface of bacteria that attach proteins to the cell wall and are involved in the construction of bacterial pili. Due to their...
4.
Vogel B, Blount J, Kodama H, Goodwin-Rice N, Andaluz D, Jackson S, et al.
RSC Chem Biol
. 2024 Jan;
5(1):30-40.
PMID: 38179192
Sortase enzymes are cysteine transpeptidases that attach environmental sensors, toxins, and other proteins to the cell surface in Gram-positive bacteria. The recognition motif for many sortases is the cell wall...
5.
Johnson D, Piper I, Vogel B, Jackson S, Svendsen J, Kodama H, et al.
J Biol Chem
. 2022 Sep;
298(10):102446.
PMID: 36055407
The cell wall is a critical extracellular barrier for bacteria and many other organisms. In bacteria, this structural layer consists of peptidoglycan, which maintains cell shape and structural integrity and...
6.
Gao M, Johnson D, Piper I, Kodama H, Svendsen J, Tahti E, et al.
Protein Sci
. 2021 Dec;
31(3):701-715.
PMID: 34939250
Sequence variation in related proteins is an important characteristic that modulates activity and selectivity. An example of a protein family with a large degree of sequence variation is that of...
7.
Boyko K, Rosenkranz E, Smith D, Miears H, Oueld Es Cheikh M, Lund M, et al.
PLoS One
. 2021 Oct;
16(10):e0258531.
PMID: 34710113
A significant number of proteins possess sizable intrinsically disordered regions (IDRs). Due to the dynamic nature of IDRs, NMR spectroscopy is often the tool of choice for characterizing these segments....
8.
Piper I, Struyvenberg S, Valgardson J, Johnson D, Gao M, Johnston K, et al.
J Biol Chem
. 2021 Jul;
297(2):100981.
PMID: 34302812
Gram-positive bacteria contain sortase enzymes on their cell surfaces that catalyze transpeptidation reactions critical for proper cellular function. In vitro, sortases are used in sortase-mediated ligation (SML) reactions for a...
9.
Reed S, Brzovic D, Takasaki S, Boyko K, Antos J
Bioconjug Chem
. 2020 Apr;
31(5):1463-1473.
PMID: 32324377
Sortase-mediated ligation is a powerful method for generating site-specifically modified proteins. However, this process is limited by the inherent reversibility of the ligation reaction. To address this, here we report...
10.
Miears H, Gruber D, Horvath N, Antos J, Young J, Sigurjonsson J, et al.
Biochemistry
. 2018 Feb;
57(11):1690-1701.
PMID: 29444403
Plants utilize multiple isoforms of villin, an F-actin regulating protein with an N-terminal gelsolin-like core and a distinct C-terminal headpiece domain. Unlike their vertebrate homologues, plant villins have a much...