John M Abrams
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Explore the profile of John M Abrams including associated specialties, affiliations and a list of published articles.
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39
Citations
4163
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Recent Articles
1.
Vitale I, Pietrocola F, Guilbaud E, Aaronson S, Abrams J, Adam D, et al.
Cell Death Differ
. 2023 Apr;
30(5):1097-1154.
PMID: 37100955
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have...
2.
Hu Y, Sun H, Sakurai M, Jones A, Liu L, Cheng T, et al.
bioRxiv
. 2023 Mar;
PMID: 36945615
Interspecies chimera formation with human pluripotent stem cells (PSCs) holds great promise to generate humanized animal models and provide donor organs for transplant. However, the approach is currently limited by...
3.
Das S, Jones A, Abrams J
Mob DNA
. 2022 Dec;
13(1):30.
PMID: 36461093
Background: LINE-1s, Alus and SVAs are the only retrotransposition competent elements in humans. Their mobilization followed by insertional mutagenesis is often linked to disease. Apart from these rare integration events,...
4.
Wylie A, Jones A, Das S, Lu W, Abrams J
Dev Cell
. 2022 Jul;
57(15):1833-1846.e6.
PMID: 35820415
p53 genes are conserved transcriptional activators that respond to stress. These proteins can also downregulate genes, but the mechanisms are not understood and are generally assumed to be indirect. Here,...
5.
Gu Z, Liu Y, Zhang Y, Cao H, Lyu J, Wang X, et al.
Nat Genet
. 2021 Apr;
53(5):672-682.
PMID: 33833453
Transposable elements or transposons are major players in genetic variability and genome evolution. Aberrant activation of long interspersed element-1 (LINE-1 or L1) retrotransposons is common in human cancers, yet their...
6.
Tiwari B, Jones A, Caillet C, Das S, Royer S, Abrams J
Genes Dev
. 2020 Oct;
34(21-22):1439-1451.
PMID: 33060137
p53 is a potent tumor suppressor and commonly mutated in human cancers. Recently, we demonstrated that p53 genes act to restrict retrotransposons in germline tissues of flies and fish but...
7.
Chen P, Visokay S, Abrams J
Fly (Austin)
. 2020 Jul;
14(1-4):3-9.
PMID: 32615907
Glutamine: fructose-6-phosphate amidotransferase (GFAT) enzymes catalyse the first committed step of the hexosamine biosynthesis pathway (HBP) using glutamine and fructose-6-phosphate to form glucosamine-6-phosphate (GlcN6P). Numerous species (e.g. mouse, rat, zebrafish,...
8.
Kurtz P, Jones A, Tiwari B, Link N, Wylie A, Tracy C, et al.
Mol Biol Cell
. 2019 Mar;
30(11):1339-1351.
PMID: 30892991
is the most frequently mutated gene in human cancers, and despite intensive research efforts, genome-scale studies of p53 function in whole animal models are rare. The need for such in...
9.
Abrams J, Arkhipova I, Belfort M, Boeke J, Curcio M, Faulkner G, et al.
Mob DNA
. 2018 Sep;
9:21.
PMID: 30211913
The Mobile Genetic Elements and Genome Plasticity conference was hosted by Keystone Symposia in Santa Fe, NM USA, February 11-15, 2018. The organizers were Marlene Belfort, Evan Eichler, Henry Levin...
10.
Tiwari B, Jones A, Abrams J
Trends Genet
. 2018 Sep;
34(11):846-855.
PMID: 30195581
p53, the most commonly mutated tumor suppressor, is a transcription factor known to regulate proliferation, senescence, and apoptosis. Compelling studies have found that p53 may prevent oncogenesis through effectors that...