John L Ryan
Overview
Explore the profile of John L Ryan including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
394
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0
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Recent Articles
1.
Zanin-Zhorov A, Weiss J, Trzeciak A, Chen W, Zhang J, Nyuydzefe M, et al.
J Immunol
. 2017 Apr;
198(10):3809-3814.
PMID: 28389592
Targeted inhibition of Rho-associated kinase (ROCK)2 downregulates the proinflammatory T cell response while increasing the regulatory arm of the immune response in animals models of autoimmunity and Th17-skewing human cell...
2.
Weiss G, Chao J, Neidhart J, Ramanathan R, Bassett D, Neidhart J, et al.
Invest New Drugs
. 2013 Feb;
31(4):986-1000.
PMID: 23397498
Patients with advanced solid malignancies were enrolled to an open-label, single-arm, dose-escalation study, in which CRLX101 was administered intravenously over 60 min among two dosing schedules, initially weekly at 6,...
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Pathways activated during human asthma exacerbation as revealed by gene expression patterns in blood
Bjornsdottir U, Holgate S, Reddy P, Hill A, McKee C, Csimma C, et al.
PLoS One
. 2011 Jul;
6(7):e21902.
PMID: 21779351
Background: Asthma exacerbations remain a major unmet clinical need. The difficulty in obtaining airway tissue and bronchoalveolar lavage samples during exacerbations has greatly hampered study of naturally occurring exacerbations. This...
5.
Duvic M, Sherman M, Wood G, Kuzel T, Olsen E, Foss F, et al.
J Am Acad Dermatol
. 2006 Oct;
55(5):807-13.
PMID: 17052486
Background: Interleukin-12 (IL-12) increases Th(1) cytokines, natural killer (NK) cells, and cytotoxic T-cell activities. Progression of mycosis fungoides is associated with Th(2) cytokines produced by a clonal proliferation of epidermotropic...
6.
Hurko O, Ryan J
NeuroRx
. 2006 Feb;
2(4):671-82.
PMID: 16489374
Of all the therapeutic areas, diseases of the CNS provide the biggest challenges to translational research in this era of increased productivity and novel targets. Risk reduction by translational research...
7.
Kikuchi T, Akasaki Y, Abe T, Fukuda T, Saotome H, Ryan J, et al.
J Immunother
. 2004 Nov;
27(6):452-9.
PMID: 15534489
Despite aggressive treatment, the median survival of patients with high-grade malignant astrocytoma is about 1 year. The authors investigated the safety and clinical response to immunotherapy using fusions of dendritic...
8.
Venkatesan A, Agarwal A, Abe T, Ushirogochi H, Yamamura I, Kumagai T, et al.
Bioorg Med Chem
. 2004 Oct;
12(22):5807-17.
PMID: 15498657
Beta-lactamases are serine and metallo-dependent enzymes produced by the bacteria in defense against beta-lactam antibiotics. Production of class-A, class-B, and class-C enzymes by the bacteria make the use of beta-lactam...
9.
Cotreau M, Warren S, Ryan J, Fleckenstein L, Vanapalli S, Brown K, et al.
J Clin Pharmacol
. 2003 Oct;
43(10):1108-15.
PMID: 14517193
A study in healthy male volunteers was completed to evaluate the safety, tolerability, and pharmacokinetics of a single oral dose of the antiparasitic moxidectin (MOX). This drug is registered worldwide...
10.
Gao J, Diesl V, Wittmann T, Morrison D, Ryan J, Vogel S, et al.
J Endotoxin Res
. 2003 Aug;
9(4):237-43.
PMID: 12935354
Bacterial DNA containing unmethylated CpG dinucleotides (CpG DNA) is a potent immune stimulating agent that holds strong promise in the treatment of many disorders. Studies have established that CpG DNA...