John L Fowlkes
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Explore the profile of John L Fowlkes including associated specialties, affiliations and a list of published articles.
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52
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1219
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Recent Articles
1.
Wyler S, Gahlot S, Bideyan L, Yip C, Dushime J, Chen B, et al.
Endocrinology
. 2024 Oct;
165(12).
PMID: 39467326
Genome-wide association studies (GWAS) in humans and livestock have identified genes associated with metabolic traits. However, the causality of many of these genes on metabolic homeostasis is largely unclear due...
2.
Bunn R, Adatorwovor R, Smith R, Ray P, Fields S, Keeble A, et al.
JBMR Plus
. 2023 Nov;
7(11):e10833.
PMID: 38025035
Type 1 diabetes (T1D) is associated with low bone and muscle mass, increased fracture risk, and impaired skeletal muscle function. Myostatin, a myokine that is systemically elevated in humans with...
3.
Suresh Kumar H, Barnett E, Fowlkes J, Kalaitzoglou E, Annamalai R
JBMR Plus
. 2023 Nov;
7(11):e10804.
PMID: 38025033
Diabetes is a chronic metabolic disorder that can lead to diabetic myopathy and bone diseases. The etiology of musculoskeletal complications in such metabolic disorders and the interplay between the muscular...
4.
Thrailkill K, Kalaitzoglou E, Fowlkes J
Front Pediatr
. 2022 Oct;
10:1012816.
PMID: 36304528
In recent years, new therapies for the treatment of rare pediatric bone disorders have emerged, guided by an increasing understanding of the genetic and molecular etiology of these diseases. Herein,...
5.
McDonald S, Ray P, Bunn R, Fowlkes J, Thrailkill K, Popescu I
Acta Histochem
. 2022 Aug;
124(7):151940.
PMID: 35969910
A primary underlying defect makes β-cells "susceptible" to no longer compensate for the peripheral insulin resistance and to trigger the onset of type 2 diabetes (T2D). New evidence suggests that...
6.
Kalaitzoglou E, Fowlkes J, Thrailkill K
Curr Opin Endocrinol Diabetes Obes
. 2022 Jun;
29(4):318-325.
PMID: 35749285
Purpose Of Review: In this review, we describe the three primary mouse models of insulin-deficiency diabetes that have been used to study the effects of type 1 diabetes (T1D) on...
7.
Fowlkes J, Thrailkill K, Bunn R
Bone
. 2021 Jun;
152:116060.
PMID: 34144233
The RASopathies comprise an ever-growing number of clinical syndromes resulting from germline mutations in components of the RAS/MAPK signaling pathway. While multiple organs and tissues may be affected by these...
8.
Hughes C, Mussman G, Ray P, Bunn R, Cornea V, Thrailkill K, et al.
Cell Tissue Res
. 2021 Jan;
384(2):527-543.
PMID: 33409652
Inhibitors of sodium/glucose co-transporter 2 (SGLT2) are currently in clinical use for type 2 diabetes (T2D) treatment due to their anti-hyperglycemic effect exerted by the inhibition of glucose reabsorption in...
9.
Thrailkill K, Bunn R, Uppuganti S, Ray P, Popescu I, Kalaitzoglou E, et al.
Bone
. 2020 Sep;
141:115625.
PMID: 32890778
Higher fracture risk in type 2 diabetes (T2D) is attributed to disease-specific deficits in micro-structural and material properties of bone, although the primary cause is not yet established. The TallyHO...
10.
Fowlkes J, Bunn R, Kalaitzoglou E, Ray P, Popescu I, Thrailkill K
Sci Rep
. 2020 Jun;
10(1):8842.
PMID: 32483283
The relationship between osteoblast-specific insulin signaling, osteocalcin activation and gluco-metabolic homeostasis has proven to be complex and potentially inconsistent across animal-model systems and in humans. Moreover, the impact of postnatally...