John K L Wong
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Explore the profile of John K L Wong including associated specialties, affiliations and a list of published articles.
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14
Citations
237
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Recent Articles
1.
Wong J, Jassowicz L, Herold-Mende C, Seiffert M, Mallm J, Lichter P, et al.
BMC Bioinformatics
. 2023 Aug;
24(1):326.
PMID: 37653401
Background: Here we present scSNPdemux, a sample demultiplexing pipeline for single-cell RNA sequencing data using natural genetic variations in humans. The pipeline requires alignment files from Cell Ranger (10× Genomics),...
2.
Khalid U, Simovic M, Hammann L, Iskar M, Wong J, Kumar R, et al.
Int J Cancer
. 2022 Apr;
151(4):590-606.
PMID: 35411591
Chromothripsis is a form of genomic instability characterized by the occurrence of tens to hundreds of clustered DNA double-strand breaks in a one-off catastrophic event. Rearrangements associated with chromothripsis are...
3.
Wong J, Aichmuller C, Schulze M, Hlevnjak M, Elgaafary S, Lichter P, et al.
Nat Commun
. 2022 Jan;
13(1):178.
PMID: 35013316
Cancer driving mutations are difficult to identify especially in the non-coding part of the genome. Here, we present sigDriver, an algorithm dedicated to call driver mutations. Using 3813 whole-genome sequenced...
4.
Hanna B, Llao-Cid L, Iskar M, Roessner P, Klett L, Wong J, et al.
Immunity
. 2021 Dec;
54(12):2825-2841.e10.
PMID: 34879221
T cell exhaustion limits anti-tumor immunity and responses to immunotherapy. Here, we explored the microenvironmental signals regulating T cell exhaustion using a model of chronic lymphocytic leukemia (CLL). Single-cell analyses...
5.
Simovic M, Bolkestein M, Moustafa M, Wong J, Korber V, Benedetto S, et al.
Neuro Oncol
. 2021 May;
23(12):2028-2041.
PMID: 34049392
Background: Medulloblastomas with chromothripsis developing in children with Li-Fraumeni Syndrome (germline TP53 mutations) are highly aggressive brain tumors with dismal prognosis. Conventional photon radiotherapy and DNA-damaging chemotherapy are not successful...
6.
Bolkestein M, Wong J, Thewes V, Korber V, Hlevnjak M, Elgaafary S, et al.
Cancer Res
. 2020 Sep;
80(22):4918-4931.
PMID: 32973084
Chromothripsis is a form of genome instability by which a presumably single catastrophic event generates extensive genomic rearrangements of one or a few chromosomes. Widely assumed to be an early...
7.
Voronina N, Wong J, Hubschmann D, Hlevnjak M, Uhrig S, Heilig C, et al.
Nat Commun
. 2020 May;
11(1):2320.
PMID: 32385320
Chromothripsis is a recently identified mutational phenomenon, by which a presumably single catastrophic event generates extensive genomic rearrangements of one or a few chromosome(s). Considered as an early event in...
8.
Hsu J, Zhang R, Yeung F, Tang C, Wong J, So M, et al.
ERJ Open Res
. 2019 Feb;
5(1).
PMID: 30740464
Background: Newborns affected with congenital pulmonary airway malformations (CPAMs) may present with severe respiratory distress or remain asymptomatic. While surgical resection is the definitive treatment for symptomatic CPAMs, prophylactic elective...
9.
Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors
Ratnaparkhe M, Wong J, Wei P, Hlevnjak M, Kolb T, Simovic M, et al.
Nat Commun
. 2018 Nov;
9(1):4760.
PMID: 30420702
Chromothripsis and chromoanasynthesis are catastrophic events leading to clustered genomic rearrangements. Whole-genome sequencing revealed frequent complex genomic rearrangements (n = 16/26) in brain tumors developing in mice deficient for factors...
10.
Wong J, Gui H, Kwok M, Ng P, Lui C, Baum L, et al.
Neurol Genet
. 2018 Jun;
4(3):e245.
PMID: 29904720
Objective: We investigated the role of rare genetic variants and of de novo variants in the pathogenesis of mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS). Methods: Whole-exome sequencing...