John J Wysolmerski
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Explore the profile of John J Wysolmerski including associated specialties, affiliations and a list of published articles.
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38
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1267
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Recent Articles
11.
Kim W, Wysolmerski J
Front Physiol
. 2016 Oct;
7:440.
PMID: 27746743
The calcium-sensing receptor (CaSR) is expressed in normal breast epithelial cells and in breast cancer cells. During lactation, activation of the CaSR in mammary epithelial cells increases calcium transport into...
12.
Jeong J, VanHouten J, Dann P, Kim W, Sullivan C, Yu H, et al.
Proc Natl Acad Sci U S A
. 2016 Jan;
113(3):E282-90.
PMID: 26729871
In the lactating mammary gland, the plasma membrane calcium ATPase2 (PMCA2) transports milk calcium. Its expression is activated in breast cancers, where high tumor levels predict increased mortality. We find...
13.
Boras-Granic K, Dann P, Wysolmerski J
Breast Cancer Res
. 2014 Dec;
16(6):487.
PMID: 25467960
Introduction: Studies have identified multi-potent stem cells in the adult mammary gland. More recent studies have suggested that the embryonic mammary gland may also contain stem/progenitor cells that contribute to...
14.
Wysolmerski J
Bonekey Rep
. 2013 Dec;
1:229.
PMID: 24363929
Over 100 years ago it was suggested that osteocytes could remodel their surrounding environment by removing and replacing bone. In the 1960s and 1970s, many observations were made to suggest...
15.
VanHouten J, Wysolmerski J
Best Pract Res Clin Endocrinol Metab
. 2013 Jul;
27(3):403-14.
PMID: 23856268
Normal breast epithelial cells and breast cancer cells express the calcium-sensing receptor (CaSR), the master regulator of systemic calcium metabolism. During lactation, activation of the CaSR in mammary epithelial cells...
16.
Wysolmerski J
Bone
. 2013 Jan;
54(2):230-6.
PMID: 23352996
Lactation is associated with an increased demand for calcium and is accompanied by a remarkable cycle of bone loss and recovery that helps to supply calcium and phosphorus for milk...
17.
Wysolmerski J
J Clin Endocrinol Metab
. 2012 Jun;
97(9):2947-56.
PMID: 22745236
PTHrP was identified as a cause of hypercalcemia in cancer patients 25 yr ago. In the intervening years, we have learned that PTHrP and PTH are encoded by related genes...
18.
Boras-Granic K, Wysolmerski J
Breast Cancer Res
. 2012 May;
14(2):307.
PMID: 22546075
Parathyroid hormone-related protein (PTHrP) causes hypercalcemia in cancer patients. PTHrP is required for normal breast development and has been shown to promote bone metastases from breast cancers. However, whether the...
19.
Liu X, Ardeshirpour L, VanHouten J, Shane E, Wysolmerski J
J Bone Miner Res
. 2011 Dec;
27(4):865-75.
PMID: 22189918
Despite the dramatic bone loss that occurs during lactation, bone mineral density rapidly recovers after offspring are weaned and milk production stops. The goal of this study is to quantify...
20.
Kirby B, Ardeshirpour L, Woodrow J, Wysolmerski J, Sims N, Karaplis A, et al.
J Bone Miner Res
. 2011 Feb;
26(6):1242-51.
PMID: 21308774
Mice lose 20% to 25% of trabecular bone mineral content (BMC) during lactation and restore it after weaning through unknown mechanisms. We found that tibial Pthrp mRNA expression was upregulated...