Brian T Ho
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Explore the profile of Brian T Ho including associated specialties, affiliations and a list of published articles.
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14
Citations
1357
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Recent Articles
1.
Virgo M, Mostowy S, Ho B
Trends Microbiol
. 2025 Jan;
PMID: 39799088
Within both abiotic and host environments, bacteria typically exist as diverse, multispecies communities and have crucial roles in human health, agriculture, and industry. In these communities, bacteria compete for resources,...
2.
Menendez-Gil P, Veleva D, Virgo M, Zhang J, Ramalhete R, Ho B
J Bacteriol
. 2024 Sep;
206(10):e0014224.
PMID: 39292012
Importance: Given the prevalence of antibiotic resistance, there is an increasing need to develop alternative approaches to managing pathogenic bacteria. In this work, we explore the feasibility of modulating the...
3.
Virgo M, Mostowy S, Ho B
PLoS Pathog
. 2024 Jul;
20(7):e1012384.
PMID: 39024393
Interbacterial competition is known to shape the microbial communities found in the host, however the interplay between this competition and host defense are less clear. Here, we use the zebrafish...
4.
Vadakkepat A, Xue S, Redzej A, Smith T, Ho B, Waksman G
Structure
. 2024 Jul;
32(9):1335-1347.e5.
PMID: 39002540
Bacterial conjugation is a process by which DNA is transferred unidirectionally from a donor cell to a recipient cell. It is the main means by which antibiotic resistance genes spread...
5.
Ho B
J Bacteriol
. 2019 Oct;
202(1).
PMID: 31636106
There is an inseverable link between the size of a cell and the size of its subcellular components. The type 6 secretion system (T6SS) is no exception. In this issue,...
6.
Zeng X, Chi X, Ho B, Moon D, Lambert C, Hall R, et al.
mSystems
. 2019 Mar;
4(1).
PMID: 30834329
Extensive drug resistance (XDR) is an escalating global problem. Escherichia coli strain Sanji was isolated from an outbreak of pheasant colibacillosis in Fujian province, China, in 2011. This strain has...
7.
Toska J, Ho B, Mekalanos J
Proc Natl Acad Sci U S A
. 2018 Jul;
115(31):7997-8002.
PMID: 30021850
The type 6 secretion system (T6SS) is a nanomachine used by many Gram-negative bacteria, including , to deliver toxic effector proteins into adjacent eukaryotic and bacterial cells. Because the activity...
8.
Fu Y, Ho B, Mekalanos J
Cell Host Microbe
. 2018 Feb;
23(2):274-281.e2.
PMID: 29398650
Vibrio cholerae is the causative agent of the diarrheal disease cholera. Although many V. cholerae virulence factors have been studied, the role of interbacterial interactions within the host gut and...
9.
Ho B, Fu Y, Dong T, Mekalanos J
Proc Natl Acad Sci U S A
. 2017 Aug;
114(35):9427-9432.
PMID: 28808000
The type 6 secretion system (T6SS) is used by many Gram-negative bacterial species to deliver toxic effector proteins into nearby bacteria prey cells to kill or inhibit their growth. VgrG...
10.
Ho B, Dong T, Mekalanos J
Cell Host Microbe
. 2013 Dec;
15(1):9-21.
PMID: 24332978
The bacterial type VI secretion system (T6SS) is an organelle that is structurally and mechanistically analogous to an intracellular membrane-attached contractile phage tail. Recent studies determined that a rapid conformational...