John Howl
Overview
Explore the profile of John Howl including associated specialties, affiliations and a list of published articles.
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39
Citations
287
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Recent Articles
1.
Matos B, S Gomes A, Bernardino R, Alves M, Howl J, Jeronimo C, et al.
Pharmaceutics
. 2024 Sep;
16(9).
PMID: 39339236
Protein phosphatase 1 (PP1) complexes have emerged as promising targets for anticancer therapies. The ability of peptides to mimic PP1-docking motifs, and so modulate interactions with regulatory factors, has enabled...
2.
Kobrock A, Matos B, Patricio D, Grenho L, Howl J, Fardilha M, et al.
Cells
. 2024 Jul;
13(13.
PMID: 38994993
The reparative and regenerative capabilities of dental pulp stem cells (DPSCs) are crucial for responding to pulp injuries, with protein phosphatase 1 (PP1) playing a significant role in regulating cellular...
3.
Jones S, Matos B, Dennison S, Fardilha M, Howl J
Pharmaceutics
. 2023 Aug;
15(8).
PMID: 37631231
Djeya1 (RKLAFRYRRIKELYNSYR) is a very effective cell penetrating peptide (CPP) that mimics the α5 helix of the highly conserved Eya domain (ED) of eyes absent (Eya) proteins. The objective of...
4.
Corda P, Moreira J, Howl J, Oliveira P, Fardilha M, Silva J
World J Mens Health
. 2023 Apr;
42(1):71-91.
PMID: 37118964
Purpose: The advent of proteomics provides new opportunities to investigate the molecular mechanisms underlying male infertility. The selection of relevant targets based on a single analysis is not always feasible,...
5.
Howl J, Silva J, Fardilha M, Jones S
Methods Mol Biol
. 2021 Nov;
2383:293-306.
PMID: 34766298
The mature spermatozoon, a highly differentiated cell equipped for the sole purpose of fertilization, lacks the protein machinery required for conventional endocytotic mechanisms. Perhaps contrary to expectation, cell-penetrating peptides (CPPs)...
6.
Santiago J, Silva J, Howl J, Santos M, Fardilha M
Hum Reprod Update
. 2021 Oct;
28(1):67-91.
PMID: 34624094
Background: Spermatogenesis generates a small and highly specialised type of cell that is apparently incapable of transcription and translation. For many years, this dogma was supported by the assumption that...
7.
Matos B, Howl J, Jeronimo C, Fardilha M
Drug Discov Today
. 2021 Aug;
26(11):2680-2698.
PMID: 34390863
Cancer is the second leading cause of death worldwide. Despite the availability of numerous therapeutic options, tumor heterogeneity and chemoresistance have limited the success of these treatments, and the development...
8.
Matos B, Patricio D, Henriques M, Freitas M, Vitorino R, Duarte I, et al.
Cell Oncol (Dordr)
. 2020 Oct;
44(2):311-327.
PMID: 33074478
Purpose: Prostate cancer is a major cause of cancer-related death in males worldwide and, in addition to impairing prostate function, also causes testicular adaptations. In this study, we aim to...
9.
Silva J, Freitas M, Santiago J, Jones S, Guimaraes S, Vijayaraghavan S, et al.
Fertil Steril
. 2020 Sep;
115(2):348-362.
PMID: 32977940
Objective: To design protein phosphatase 1 (PP1)-disrupting peptides covalently coupled to inert cell-penetrating peptides (CPPs) as sychnologically organized bioportide constructs as a strategy to modulate sperm motility. Design: Experimental study....
10.
Matos B, Howl J, Jeronimo C, Fardilha M
Pharmacol Res
. 2020 Aug;
161:105145.
PMID: 32814172
Prostate cancer (PCa) is one of the most common male-specific cancers worldwide, with high morbidity and mortality rates associated with advanced disease stages. The current treatment options of PCa are...